Summary
Two sarcomas, one neurosarcoma and one polymorphous tumour of uncertain classification of the central nervous system of the rat induced by N-nitrosomethylurea or ethylnitrosourea were the source of 14 clones. The cytomorphology and the aggregation pattern of the clonesin vitro are described. The malignancy and histology were checked by homologous transplantation. All the clones formed sarcoma-like structuresin vivo, but it was difficult to decide whether these neoplasias were real sarcomas or very dedifferentiated glial tumours. The differences in cytology observedin vitro were greater than the histological differencesin vivo.
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Thust, R., Warzok, R. Comparative studies on thein vitro andin vivo morphology of clones of experimental CNS tumours in the rat. Acta Neuropathol 20, 248–257 (1972). https://doi.org/10.1007/BF00686906
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DOI: https://doi.org/10.1007/BF00686906