Summary
Electron microscopy revealed the presence of cytoplasmic tubular aggregates in the capillary endothelium of a sparsely granulated growth hormone cell adenoma removed surgically from a 25-year-old female patient with acromegaly. To our knowledge, this is the second publication describing these structures in hypophysial growth hormone cell adenomas.
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References
Baringer, J. R.: Tubular aggregates in endoplasmic reticulum in herpes-simplex encephalitis. New Engl. J. Med.285, 943–945 (1971)
Baringer, J. R., Swoveland, P.: Tubular aggregates in endoplasmic reticulum: evidence against their viral nature. J. Ultrastruct. Res.41, 270–276 (1972)
Berk, S. H., Blank, H.: Ultraviolet light and cytoplasmic tubules in lupus erythematosus. Arch. Derm.109, 364–366 (1974)
Bloodworth, J. M. B. Jr., Shelp, W. D.: Endothelial cytoplasmic inclusions. Arch. Path.90, 252–258 (1970)
Curé, M., Trouillas, J., Lheritier, M., Girod, C., Rollet, J.: Inclusions tubulaires dans une tumeur hypophysaire. Nouv Presse méd.1, 2309–2311 (1972)
Eady, R. A. J., Odland, G. F.: Intraendothelial tubular aggregates in experimental wounds. Ultrastructural study. Brit. J. Derm.93, 165–173 (1975)
Gaal, J. M., Horvath, E., Kovacs, K.: Ultrastructure of two cases of anaplastic giant cell tumor of the human thyroid gland. Cancer35, 1273–1279 (1975)
Garancis, J. C., Komorowski, R. A., Bernhard, G. C., Straumfjord, J. V.: Significance of cytoplasmic microtubules in lupus nephritis. Amer. J. Path.64, 1–12 (1971)
Grimley, P. M., Barry, D. W., Schaff, Z.: Induction of tubular structures in the endoplasmic reticulum of human lymphoid cells by treatment with 5-bromo-2′-deoxyuridine. J. nat. Cancer Inst.51, 1751–1760 (1973)
Grimley, P. M., Decker, J. L., Michelitch, H. J., Frantz, M. M.: Abnormal structures in circulating lymphocytes from patients with systemic lupus erythematosus and related diseases. Arthri. Rheum.16, 313–323 (1973)
Györkey, F., Sinkovics, J. G., Min, K. W., Györkey, P.: A morphologic study on the occurrence and distribution of structures resembling viral nucleocapsids in collagen diseases. Amer. J. Med.52, 148–158 (1972)
Haas, J. E., Yunis, E. J.: Tubular inclusions of systemic lupus erythematosus. Ultrastructural observations regarding their possible viral nature. Exp. molec. Path.12, 257–263 (1970)
Helder, A. W., Feltkamp-Vroom, T. M., Van Loghem, J. J.: A comparative morphological study of tubular structures in human tissues and nucleocapsides of measles virus. J. micr. Biol. Cell.23, 1–16 (1975)
Hirano, A., Matsui, T.: Vascular structures in brain tumors. Human Path.6, 611–621 (1975)
Horvath, E., Kovacs, K.: Ultrastructural classification of pituitary adenomas. Canad. J. neurol. Sci.3, 9–21 (1976)
Jenson, A. B., Spjut, H. J., Smith, M. N., Rapp, F.: Intracellular branched tubular structures in osteosarcoma. An ultrastructural and serological study. Cancer27, 1440–1448 (1971)
Kinnman, J.: Acromegaly. An ultrastructural analysis of 51 adenomas and a clinical study in 80 patients treated by transanthrosphenoidal operation, pp. 1–226. Stockholm: Norstedt and Söner 1973
Klippel, J. H., Grimley, P. M., Decker, J. L., Michelitch, H. J.: Lymphocyte tubuloreticular structures in lupus erythematosus. Correlation with disease activity. Ann. intern. Med.81, 355–357 (1974)
Landolt, A. M.: Ultrastructure of human sella tumors. Acta Neurochir., Suppl.22, 1–167 (1975)
Landry, M., Winkelmann, R. K.: Tubular cytoplasmic inclusion in dermatomyositis. Proc. Mayo Clin.47, 479–492 (1972)
Macadam, R. F., Vetters, J. M., Saikia, N. K.: A search for microtubular inclusions in endothelial cells in a variety of skin diseases. Brit. J. Derm.92, 175–182 (1975)
Maciejewski, W., Dabrowski, J., Jablonska, S., Jakubowicz, K.: Virus-like tubular cytoplasmic inclusions in epithelial tumors. Electron microscopic studies. Dermatologica (Basel)146, 141–148 (1973)
Pothier, L., Uzman, B. G., Kasac, M. M., Saito, H., Adams, R. A.: Immunoglobulin synthesis and tubular arrays in the endoplasmic reticulum in transplanted human tumors of lymphoid origin. Lab. Invest.29, 607–613 (1973)
Schaff, Z., Barry, D. W., Grimley, P. M.: Cytochemistry of tubuloreticular structures in lymphocytes from patients with systemic lupus erythematosus and in cultured human lymphoid cells. Comparison to a paramyxovirus. Lab. Invest.29, 577–586 (1973)
Tisher, C. C., Kelso, H. B., Robinson, R. R., Grinnels, J. C., Burkholder, P. M.: Intraendothelial inclusions in kidneys of patients with systemic lupus erythematosus. Ann. intern. Med.75, 537–547 (1971)
Uzman, B. C., Saito, H., Kasac, M.: Tubular arrays in the endoplasmic reticulum in human tumor cells. Lab. Invest.24, 492–498 (1971)
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Kovacs, K., Horvath, E., Pritzker, K.P.H. et al. Pituitary growth hormone cell adenoma with cytoplasmic tubular aggregates in the capillary endothelium. Acta Neuropathol 37, 77–79 (1977). https://doi.org/10.1007/BF00684545
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DOI: https://doi.org/10.1007/BF00684545