Skip to main content
SpringerLink
Log in

Anterior horn cell degeneration and Bunina-type inclusions associated with dementia

  • Short Original Communications
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

The ultrastructural features of Bunina type inclusions in the anterior horn cells of a patient dying of amyotrophic lateral sclerosis with dementia appear unique. The Bunina-type inclusions are electron dense aggregates containing, and surrounded by organelle-like membranes. These inclusions appear to be a special type of autophagic vacuole, possibly arising from altered mitochondria.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Ashford, T. P., Porter, K. R.: Cytoplasmic components in hepatic cell lysosomes. J. Cell. Biol.12, 198–202 (1962)

    Google Scholar 

  • Bloom, S., Cancilla, P. A.: Myocytolysis and mitochondrial calcification in rat myocardium after low doses of isoproterenol. Amer. J. Path.54, 373–391 (1969)

    Google Scholar 

  • Bunina, T. L.: On intracellular inclusions in familial amyotrophic lateral sclerosis. Korsakov J. Neurol. Psychiat.62, 1293–1299 (1962)

    Google Scholar 

  • Johnson, P. C.: Anterior horn cell eosinophilic cytoplasmic inclusion bodies in sporadic motor neuron disease of adults. Poster Display No. 137, Amer. Assoc. Neuropathol. Annual meeting. San Francisco, Calif., June 11, 1976

  • Malamud, N., Hirano, A., Kurland, L. T.: Pathoanatomic changes in amyotrophic lateral sclerosis on Guam. Arch. Neurol. (Chic.)5, 401–415 (1961)

    Google Scholar 

  • Nelson, J. S., Prensky, A. L.: Sporadic juvenile amyotrophic lateral sclerosis. Arch. Neurol. (Chic.)27, 300–306 (1972)

    Google Scholar 

  • Suzuki, K., DePaul, L.: Cellular degeneration in developing central nervous system of rats produced by hypocholesteremic drug A&9944. Lab. Invest.25, 546–555 (1971)

    Google Scholar 

  • Takahashi, K., Nakamura, H., Okada, E.: Hereditary amyotrophic lateral sclerosis. Arch. Neurol. (Chic.)27, 292–299 (1972)

    Google Scholar 

  • Towfighi, J., Grover, W., Gonatas, N. K.: Mental retardation, hypotonia and generalized seizures associated with astrocytic “residual” bodies. Human Path.6, 667–680 (1975)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Iowa, College of Medicine, 52242, Iowa City, Iowa, USA

    Michael Noel Hart, Pasquale A. Cancilla & Stephen Frommes

  2. Devision of Neuropathology, Department of Pathology, Montefiore Hospital and Medical Center, 10467, Bronx, New York, USA

    Asao Hirano

Authors
  1. Michael Noel Hart
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pasquale A. Cancilla
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stephen Frommes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Asao Hirano
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hart, M.N., Cancilla, P.A., Frommes, S. et al. Anterior horn cell degeneration and Bunina-type inclusions associated with dementia. Acta Neuropathol 38, 225–228 (1977). https://doi.org/10.1007/BF00688069

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00688069

Key words

Search

Navigation