Summary
Paired twisted filaments (PTF) forming helices are described in tumor cells of three human pine-alomas. Each filament was 8.11±1.55 nm wide. The maximal width of the helix was 16.62±2.62 nm. The periodicity of the constrictions was 26.63±4.49 nm. These characteristics appeared original, suggesting protein, filaments possibly specific of pinealocytes. The similarities and discrepancies between PTF and Alzheimer's paired helical filaments (PHF) are discussed.
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Hassoun J, Gambarelli D, Peragut JC, Toga M (1983) Specific ultrastructural markers of human pinealomas. A study of four cases. Acta Neuropathol (Berl) 62:31–40
Herrick MK, Rubinstein LJ (1979) The cytological differentiating potential of pineal parenchymal neoplasms (true pinealomas). Brain 102:289–320
Kidd M (1963) Paired, helical filaments in electron microscopy of Alzheimer's disease. Nature 197:192–193
Kline KT, Damjanov I, Moriber-katz S, Schmidek H (1979) Pinealoblastoma: an electron microscopic study. Cancer 44:1692–1699
Markesberry WR, Haugh RM, Young AB (1981) Ultrastructure of pineal parenchyma neoplasms. Acta Neuropathol (Berl) 55:143–149
Møller M (1974) The ultrastructure of the human fetal pineal gland. I. Cell types and blood vessels. Cell Tissue Res 152:13–30
Nielsen SL, Wilson WB (1975) Ultrastructure of a “pineocytoma”. J Neuropathol, Exp Neurol 34:148–158
Peters A, Palay SL, De F, Webster H (1976) The fine structure of the nervous system. Saunders, Philadelphia
Pevet P (1979) Secretory processes in the mammalian pinealocytes under natural and experimental conditions. Prog Brain Res 52:149–194
Vollrath L (1981) The pineal organ. Springer, Berlin Heidelberg New York
Wang GP, Grundke-Iqbal I, Kascsak RJ, Iqbal, K, Wisniewski HM (1984) Alzheimer neurofibrillary tangles: monoclonal antibodies to inherent antigen(s). Acta Neuropathol (Berl) 62:259–267
Welsh MG, Reiter RJ (1978) The pineal gland of the gerbil Merions unguiculatus. I., An ultrastructural study. Cell Tissue Res 193:323–336
Wisniewski HM, Narang HK, Terry RD (1976) Neurofibrillary tangles of paired helical filaments. J Neurol Sci 27:173–181
Wisniewski K, Jervis GA, Moretz RC, Wisniewski HM (1979) Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia. Ann Neurol 5:288–294
Wisniewski HM, Merz GS, Merz PA, Wen GY, Iqbal K (1983) Morphology and biochemistry of neuronal paired helical filaments and amyloid fibers in humans and animals. In: Zimmerman HM (ed) Progress in neuropathology, vol 5. Raven Press, New York, pp 139–150
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Supported by a grant from FEGEFLUC (Fédération Nationale des Groupements des Entreprises Françaises dans la Lutte contre le Cancer), Marseille, France
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Hassoun, J., Devictor, B., Gambarelli, D. et al. Paired twisted filaments a new ultrastructural marker of human pinealomas?. Acta Neuropathol 65, 163–165 (1984). https://doi.org/10.1007/BF00690471
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DOI: https://doi.org/10.1007/BF00690471