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Thickening of the basement membrane of cortical capillaries in Alzheimer's disease

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Summary

Data concerning width and surface of the basement membrane of cortical capillaries in three patients with Alzheimer's disease five age-matched controls, have been submitted to statistical analysis to ascertain the role of the aging process upon thickening of the basement membrane itself. The analysis showed that there was a significant difference between patients with Alzheimer's disease and controls (P<0.01) as to both width and surface of the basement membrane, so suggesting that in these patients aging was not the only factor which thickening of the basement membrane of cortical capillaries was related to.

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This investigation was financially supported by Consiglio Nazionale delle Ricerche Ministro della Pubblica Istruzione, and Regione Liguria Regione Liguria

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Mancardi, G.L., Perdelli, F., Rivano, C. et al. Thickening of the basement membrane of cortical capillaries in Alzheimer's disease. Acta Neuropathol 49, 79–83 (1980). https://doi.org/10.1007/BF00692225

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  • DOI: https://doi.org/10.1007/BF00692225

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