Summary
An atypical case of senile dementia is reported which shows senile plaques, neurofibrillary tangles, granulovacuolar degeneration, and Hirano bodies and numerous Lewy bodies in the pigmented neurons of the brain stem, and Lewy-body-like inclusions in the cerebral cortex. The inclusions in the cerebral cortex had a strong resemblance to the Lewy bodies in the substantia nigra, though a few histochemical and ultrastructural differences were observed.
The pathological findings were unexpected since the parkinsonian syndrome was not recognized.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Defendini R, Markesbery WR, Mastri AR, Duffy PE (1973) Hallervorden-Spatz disease and infantile neuroaxonal dystrophy. J Neurol Sci 20:7–23
Duffy PE, Tennyson VM (1965) Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson's diesease. J Neuropathol Exp Neurol 24:398–414
Forno LS (1969) Concentric hyaline intraneural inclusions of Lewy type in the brains of elderly persons (50 incidental cases): Relationship to parkinsonism. J Am Geriatr Soc 17:557–575
Forno LS, Norville RL (1976) Ultrastructure of Lewy bodies in the stellate ganglion. Acta Neuropathol (Berl) 34:183–197
Forno LS, Barbour PJ, Norville RL (1978) Presenile dementia with Lewy bodies and neurofibrillary tangles. Arch Neurol 35:818–822
Hirano A (1976) Progress in the pathology of motor neuron disease. In: Zimmerman HM (ed) Progress in neuropathology, vol 3. Grune and Stratton, New York, London, pp 181–215
Ikeda K, Ikeda S, Yoshimura T, Kato H, Namba M (1978) Idiopathic parkinsonism with Lewy-type inclusions in cerebral cortex. A case report. Acta Neuropathol (Berl) 41:165–168
Kaiya H (1974) Spino-olivo-ponto-cerebello-nigral atrophy with Lewy bpdies and binucleated nerve cells. A case report. Acta Neuropathol (Berl) 30:263–269
Kosaka K, Oyanagi S, Matsushita M, Hori A (1976) Presenile dementia with Alzheimer- Pick- and Lewy body changes. Acta Neuropathol (Berl) 36:221–233
Kosaka K (1978) Lewy bodies in cerebral cortex. Report of three cases. Acta Neuropathol (Berl) 42:127–134
Kosaka K, Mehraein P (1979) Dementia-parkinsonism syndrome with numerous Lewy bodies and senile plaques in cerebral cortex. Arch Psychiatr Nervenkr 226:241–250
Ogasawara N, Takamatsu K, Monma Y, Itoh T (1978) Presenile Demenz mit senilen Veränderungen, argentophilen Kugeln und Lewy-Körperchen. J Neuropathol Exp Neurol 47:667
Ohama E, Ikuta F (1976) Parkinson's disease. Distribution of Lewy bodies and monoamine neuron system. Acta Neuropathol (Berl) 34:311–319
Okazaki H, Lipkin LE, Aronson SM (1961) Diffuse intracytoplasmic ganglionic inclusions (Lewy type) associated with progressive dementia and quadriparesis in flexion. J Neuropathol Exp Neurol 20:237–244
Rosenblum WI, Ghatak NR (1979) Lewy bodies in the presence of Alzheimer's disease. Arch Neurol 36:170–171
Turner B (1972) Pathology of paralysis agitans. Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 6. Elsevier, Amsterdam, pp 212–217
Watanabe I, Vachel E, Tomita T (1977) Dense core vesicles around the Lewy bodies in incidental Parkinson's disease. An electron microscopic study. Acta Neuropathol (Berl) 39:173–175
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yagishita, S., Itoh, Y., Amano, N. et al. Atypical senile dementia with widespread Lewy type inclusion in the cerebral cortex. Acta Neuropathol 49, 187–191 (1980). https://doi.org/10.1007/BF00707105
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00707105