Summary
The ceroid pigment of macrophages were subdivided into four different types according to their own color and their ability to stain with luxol fast blue. With reference to this mode a series of more than 200 brain infarcts which had happened 1 day to 56 years before death, was examined systematically. According to the results the ceroid variants do not only succeed one another chronologically but they also represent histochemically successive phases of development which correspond to the progressive auto-oxidation of unsaturated lipids. The occurrence of the different stages is chronologically defined. During this development cortical and subcortical macrophages show different speeds in the ageing process of their pigments. There is no evidence for an essential participation of proteins in the maturation of the ceroid. Not during any phase of development is the reaction pattern identical with that of neuronal and glial lipofuscin.
Similar content being viewed by others
References
Dixon KC (1953) Cytochemical changes in necrotic grey matter of the brain. J Path Bact 66:251–262
Dixon KC (1954) Cytochemistry of a cerebral scar. J Path Bact 68:85–88
Dixon KC, Gresham GA (1974) Remnants of necrotic grey matter. Acta Neuropathol (Berl) 28:55–68
Endicott KM, Lillie RD (1944) Ceroid, the pigment of dietary cirrhosis of rats. Its characteristics and its differentiation from hemofuscin. Am J Path 20:149–153
Gabe M (1976) Histochemical techniques. Masson, Paris New York Barcelona Milan, and Springer, New York Heidelberg Berlin
Gedigk P, Fischer R (1958) Über die Entstehung des Ceroidpigmentes bei der hämorrhagischen Fettgewebsnekrose. Virchows Arch Path Anat 331:341–370
Gedigk P, Fischer R (1959) Über die Entstehung von Lipopigmenten in Muskelfasern. Untersuchungen beim experimentellen Vitamin E-Mangel der Ratte und an Organen des Menschen. Virchows Arch Path Anat 332:431–468
Gedigk P, Pioch W (1965) Über die formale Genese lipogener Pigmente. Untersuchungen mit Estern hochungesättigter Fettsäuren. Virchows Arch Path Anat 339:100–135
Gedigk P, Totovié V, (1976) Lysosomen und Pigmente. Verh Dtsch Ges Path 60:64–94
Geyer G (1960) Zur Eiweißfärbung mit Amidoschwarz 10 B. Acta Histochem (Jena) 10:286–292
Gomori G (1953) Microscopical histochemistry. University of Chigaco Press, Chicago
Haitinger M (1959) Fluorescenz-Mikroskopie, 2. Aufl. Geest & Portig, Leipzig
Hamperl H (1950) Über fluorescierende Körnchenzellen (“Fluorocyten”). Virchows Arch Path Anat 318:32–47
Hartroft WS (1951) In vitro and in vivo production of a ceroid-like substance from erythrocytes and certain lipids. Science 113:673–674
Hartroft WS, Porta EA (1965) Cerod. Am J med Sci 250:324–345
Kajihara H, Totović V, Gedigk P (1975) Zur Ultrastruktur und Morphogenese des Ceroidpigments. II. Spätveränderungen der Lysosomen in Kupfferschen Sternzellen der Rattenleber nach Phagozytose hochungesättigter Lipide. Virchows Arch Cell Pathol 19:239–254
Lee S (1950) Histochemical studies of the ceroid pigment of rats and mice and its relation to necrosis. J Nat Cancer Inst 11:339–347
Lillie RD, Ashburn LL, Sebrell WH, Daft FS, Lowry JV (1942) Histogenesis and repair of the hepatic cirrhosis in rats produced on low protein diets and preventable with choline. Publ Health Rep (Wash) 57:502–508
Lillie RD, Daft FS, Sebrell WH (1941) Cirrhosis of the liver in rats on a deficient diet and the effect of alcohol. Publ Health Rep (Wash) 56:1255–1258
Lillie RD, Fullmer HM (1976) Histopathologic technic and practical histochemistry, 4th edn. McGraw-Hill, New York
Marinesco MG (1909) La cellule nerveuse, t. 2. Doin, Paris
Müller W (1962) Über das Pigment im Neurinom. Dtsch Z Nervenheilk 183:331–339
Müller W (1963) Histochemische Untersuchungen zur Genese des Pigments im Hypophysenhinterlapen des Menschen. Naturwissenschaften 50:445–446
Odefey M (1918) Untersuchungen über das Vorkommen fetthaltiger Körper und Pigmentes in den nicht nervösen Teilen des Gehirns unter normalen und krankhaften Bedingungen. Arch Psychiat Nervenkrankh 59:10–36
Pearse AGE (1960) Histochemistry, theoretical and applied. 2nd edn. Churchill, London
Petresco A (1666) Contributions histochimiques à l'étude des lipides dans les lésions démyélinisantes. Ann Histochim 11:237–252
Popper H, György P, Goldblatt H (1944) Fluorescent material (ceroid) in experimental nutritional cirrhosis. Arch Path 37:161–168
Schröder R (1978) Der zeitliche Ablauf morphologischer Veränderungen am menschlichen Zentralnervensystem nach lokalen und allgemeinen Zirkulationsstörungen. Habil.-Schrift, Köln
Schröder R, Reinartz B (1979) Das Hämoceroid, ein Lipopigment in hämorrhagischen Hirnnekrosen. Report at the Annual Meeting of the Deutsche Gesellschaft für Neuropathologie und Neuroanatomie in Essen
Schröder R, Reinartz B (1980) The phagocytic lipopigments in human brain tissue necrosis. II. Hemoceroid. Acta Neuropathol (Berl) 52:147–151
Seitelberger F (1971) Pigmentary disorders. In: Minckler J (ed) Pathology of the nervous system, vol II. McGraw-Hill, New York, pp 1324–1338
Spielmeyer W (1922) Histopathologie des Nervensystems. Springer, Berlin
Takada R (1960) A histochemical study on ceroid pigment. Trans Soc Path Jpn 49:1035–1066
Wolf A, Pappenheimer AM (1945) Occurrence and distribution of acid-fast pigment in the central nervous system. J Neuropathol Exp Neurol 4:402–406
Wolman M (1975) Biological peroxidation of lipids and membranes. Isr J Med Sci [Suppl] 11
Zollinger HU (1953) Lokalisation und Bedeutung des Ceroid-Pigmentes. Schweiz Z Allg Path 16:1026–1040
Author information
Authors and Affiliations
Additional information
Dedicated to Prof. Dr. Dr. Wilhelm Müller on April 17, 1980
Rights and permissions
About this article
Cite this article
Schröder, R. The lipopigments in human brain tissue necroses. Acta Neuropathol 52, 141–145 (1980). https://doi.org/10.1007/BF00688012
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00688012