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Attempts to suppress experimental allergic neuritis in the rat by pretreatment with antigen

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Summary

The injection of bovine dorsal root antigen in complete Freund's adjuvant can be used to produce experimental allergic neuritis (EAN) in rats. In this study attempts were made to prevent the development of the disease by prior injections of antigen. It was found that eight intradermal (i.d.) injections of antigen in either incomplete Freund's adjuvant or in saline failed to suppress EAN. A single intraperitoneal (i.p.) injection of antigen in saline produced only minimal protection against the disease. However, it was found that rats which had been given a primary course of EAN were subsequently completely unresponsive to a second injection of antigen.

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Author notes

  1. R. I. Craggs

    Present address: National Institutes of Health, National Institute of Nervous Diseases, 20205, Bethesda, MD, USA

Authors and Affiliations

  1. Dept. of Neurological Science, Royal Free Hospital School of Medicine, Rowland Hill Street, NW3 2PF, London, UK

    J. V. Brosnan, R. I. Craggs, R. H. M. King & P. K. Thomas

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  1. J. V. Brosnan
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  2. R. I. Craggs
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  3. R. H. M. King
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  4. P. K. Thomas
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Brosnan, J.V., Craggs, R.I., King, R.H.M. et al. Attempts to suppress experimental allergic neuritis in the rat by pretreatment with antigen. Acta Neuropathol 64, 153–160 (1984). https://doi.org/10.1007/BF00695579

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  • DOI: https://doi.org/10.1007/BF00695579

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