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The effect of treatment withCorynebacterium parvum on the development and growth of experimental hematogenic metastases of schwannoma in the rat

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Summary

Single i.v. administration ofCorynebacterium parvum 5 days before i.v. injection of 106 tissue cultured syngeneic schwannoma cells in Lewis rats resulted in extension of survival time (P<0.05). There was a significant decrease in metastatic tumor incidence for lung, heart, and kidney and decreased lung tumor growth with approximately 50% of the lung tumor burden of untreated controls (P<0.05). Rats treated similarly withC. parvum 10 days after tumor cell injection showed no enhanced survival; to the contrary, their survival was shortened. Moreover, tumor incidence in the post-treated group was not significantly different from the control but significantly increased in comparison to the pretreated group. Enhanced lung tumor growth resulted in a final tumor burden about twice that of untreated controls (P<0.05).

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Authors and Affiliations

  1. Surgical Cancer Research Laboratory, Mt. Sinai Medical Center, 4300 Alton Road, 33140, Miami Beach, FL, USA

    J. A. Bash

  2. Dept. of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, 231 Bethesda Ave., 45267, Cincinnati, OH, USA

    T. I. Mandybur

  3. Dept. of Pharmaceutics and of Pharmacology, College of Medicine and Pharmacy, University of Cincinnati, Cincinnati, OH, USA

    W. A. Ritschel

Authors
  1. J. A. Bash
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  2. T. I. Mandybur
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  3. W. A. Ritschel
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Additional information

Supported in part by National Cancer Institute Contract N01-C7-3307 and PHS General Research Support Grant to the University of Cincinnati, College of Medicine

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Bash, J.A., Mandybur, T.I. & Ritschel, W.A. The effect of treatment withCorynebacterium parvum on the development and growth of experimental hematogenic metastases of schwannoma in the rat. Acta Neuropathol 68, 22–26 (1985). https://doi.org/10.1007/BF00688951

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  • DOI: https://doi.org/10.1007/BF00688951

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