Skip to main content
Log in

Glioblastoma with sarcomatous component associated with myxoid change

A histochemical, immunohistochemical and electron microscopic study

  • Original Works
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

The case of a 22-year-old female suffering from glioblastoma with sarcomatous component (WHO; gliosarcoma) is presented. The tumor consisted of glioblastomatous and sarcomatouos components, and in part of the pleomorphic astrocytomatous region of the glioblastoma there was a prominent production of myxoid matrix. On the basis of its histochemical and immunohistochemical characteristics, the present case strongly suggested that glial cells of neuroectodermal origin assume part of the responsibility for production of myxoid material.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Chung EB, Enzinger FM (1976) Infantile fibrosarcoma. Cancer 38:729–739

    Google Scholar 

  • Feigin IH, Gross SW (1955) Sarcoma arising in glioblastoma of the brain. Am J Pathol 31:633–653

    Google Scholar 

  • Feigin I, Allen LB, Lipkin L, Gross SW (1958) The endothelial hyperplasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation. Cancer 11:264–277

    Google Scholar 

  • Goldman RL (1969) Gliomyosarcoma of the cerebrum. Report of a unique case. Am J Clin Pathol 52:741–744

    Google Scholar 

  • Kepes JJ, Fulling KH, Garcia JH (1982) The clinical significance of “adenoid” formations of neoplastic astrocytes, imitating metastatic carcinoma, in gliosarcomas: a review of five cases. Clin Neuropathol 1:139–150

    Google Scholar 

  • Kepes JJ, Rubinstein LJ, Chiang H (1984) The role of astrocytes in the formation of cartilage in gliomas. An immunohistochemical study of four cases. Am J Pathol 117:471–481

    Google Scholar 

  • Kishikawa M, Tsuda N, Shimizu K, Takiguchi K, Takaki Y, Yushita Y, Araki J, Nishimori I, Fujii H (1981) Ultrastructural study of the myxomatous change of peripheral nerve tumor. J Clin Electron Microsc 14:831–832

    Google Scholar 

  • Kishikawa M, Tsuda N, Shimizu K, Takaki Y, Yushita Y, Fujii H, Nishimori I (1982) Ultrastructural study of proliferated small vessels in brain tumor. J Clin Electron Microsc 15:787–788

    Google Scholar 

  • Lalitha VS, Rubinstein LJ (1979) Reactive glioma in intracranial sarcoma: a form of mixed sarcoma and glioma (“sarcoglioma”). Report of eight cases. Cancer 43:246–257

    Google Scholar 

  • Morantz RA, Feigin I, Ransohoff III J (1976) Clinical and pathological study of 24 cases of gliosarcoma. J Neurosurg 45:398–408

    Google Scholar 

  • Richman AV, Balis GA, Maniscalco JE (1980) Primary intracerebral tumor with mixed chondrosarcoma and glioblastoma-gliosarcoma or sarcoglioma? J Neuropathol Exp Neurol 39:329–335

    Google Scholar 

  • Rubinstein LJ (1972) Tumors of the central nervous system. Armed Forces Institute of Pathology, Washington DC, pp 74–78 and 198–199

    Google Scholar 

  • Saku T, Tsuda N, Anami M, Okabe H (1985) Smooth and skeletal myosins in spindle cells tumors of soft tissue: an immunohistochemical study. Acta Pathol Jpn 35:125–136

    Google Scholar 

  • Sarmiento J, Ferrer I, Pons L, Ferrer E (1979) Cerebral mixed tumour: Osteo-chondrosarcoma- Glioblastoma multiforme. Report of one case. Acta Neurochir 50:335–341

    Google Scholar 

  • Schiffer D, Giordana MT, Mauro A, Migheli A (1984) GFAP, F VIII/RAg, laminin, and fibronectin in gliosarcomas: an immunohistochemical study. Acta Neuropathol (Berl) 63:108–116

    Google Scholar 

  • Slowik F, Jellinger K, Gas zo L, Fischer J (1985) Gliosarcomas: histological, immunohistochemical, ultrastructural, and tissue culture studies. Acta Neuropathol (Berl) 67:201–210

    Google Scholar 

  • Stroebe H (1895) Ueber Entstehung und Bau der Gehirngliome. Beitr Pathol Anat Allg Pathol 18:405–486

    Google Scholar 

  • Zülch KJ (1979) Histological typing of tumours of the central nervous system. World Health Organization, Geneva

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kishikawa, M., Tsuda, N., Fujii, H. et al. Glioblastoma with sarcomatous component associated with myxoid change. Acta Neuropathol 70, 44–52 (1986). https://doi.org/10.1007/BF00689513

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00689513

Key words

Navigation