Summary
Employing the freeze-fracture technique, the distribution of filipin-sterol complexes was determined for membranes of peripheral nerve myelin. A heterogeneous distribution of complexes was observed with the greatest abundance on membranes associated with the cytoplasmic channels of Schmidt-Lanterman and longitudinal incisures. In addition there was an irregular network of well-labelled membrane bands in compact myelin. The results are related to a possible role for these channels and bands in the biochemical turnover of cholesterol in myelin.
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Blanchard, C.E., Sikri, K. & Allt, G. Filipin-sterol complexes at Schmidt-Lanterman incisures. Acta Neuropathol 72, 355–361 (1987). https://doi.org/10.1007/BF00687267
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DOI: https://doi.org/10.1007/BF00687267