Summary
A series of 16 cerebellar medulloblastomas were studied immunohistochemically using a four-step immunoperoxidase (PAP) method and a monoclonal antibody (MAbA9-C6) which defines an epitope of the retinal S-antigen, a protein known to occur in retinal photoreceptor cells and pinealocytes of the pineal gland as well as in retinoblastomas, pineocytomas and pineoblastomas. Immunopositivity was demonstrated in a variable number of tumor cells in 50% of the cases. This finding may be an indication of a differentiation potential of medulloblastomas along the photoreceptor cell lineage. Alternatively, it may simply indicate the non-specificity of the retinal antigen in the neoplastic state.
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Supported by a grant-in-aid from the Department of Pathology, University of Alabama at Birmingham (JMB) and by a grant from the Fondation Suisse de Médecine et Biologie (EP)
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Bonnin, J.M., Perentes, E. Retinal S-antigen immunoreactivity in medulloblastomas. Acta Neuropathol 76, 204–207 (1988). https://doi.org/10.1007/BF00688104
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DOI: https://doi.org/10.1007/BF00688104