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Membranous changes in primary malignant CNS lymphomas

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Summary

Ultrastructural studies of 17 primary malignant CNS lymphomas revealed 6 tumors with abnormal intracytoplasmic and/or intranuclear membranous structures, most frequently, associated with the endoplasmic reticulum or perinuclear envelope. In most cases, tubuloreticular inclusions and paired cisternae were present. Less frequent were accumulation of mictotubules, concentric lamellar bodies, and rod-like or paracrystalline intranuclear inclusions. The specificity and significance of these membranous structures remain questionable because of their frequent occurrence in a variety of normal and pathological conditions. Some of these changes may be considered as cellular reactions to viral infections, others may indicate cellular activity or degeneration.

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References

  1. Baringer JR (1971) Tubular aggregates in endoplasmic reticulum in herpes simplex encephalitis. N Eng J Med 285:943–945

    Google Scholar 

  2. Baringer JR, Swoveland P (1972) Tubular aggregates in endoplasmic reticulum: evidence against their viral nature. J Ultrastruct Res 41:270–276

    Google Scholar 

  3. Bashir RM, Harris NL, Hochberg FH, Singer RM (1989) Detection of Epstein-Barr virus in CNS lymphomas by insitu hybridization. Neurology 39:813–817

    Google Scholar 

  4. Bockus D, Remington F, Luu J, Bean M, Hammar S (1988) Induction of cylindrical confronting cisternae (AIDS inclusions) in Daudi lymphoblastoid cells by recombinant α-interferon. Hum Pathol 19:70–82

    Google Scholar 

  5. Buck RC (1961) Lamellae in the spindle of mitotic cells of Walker 256 carcinoma. J Biophys Biochem Cytol 11:227–236

    Google Scholar 

  6. Chandra S (1968) Undulating tubules associated with endoplasmic reticulum in pathologic tissues. Lab Invest 18:422–428

    Google Scholar 

  7. Feremans WW, Hyugen K, Menu R (1988) Fifty cases of human immunodeficiency virus (HIV) infection: immunoultrastructural study of circulating lymphocytes. J Clin Pathol 41:62–71

    Google Scholar 

  8. Ghadially FN (1975) Ultrastructural pathology of the cell. Butterworths, London, Boston, pp 62–74, 209–282

    Google Scholar 

  9. Goodman JR, Sylvester RA, Talal N, Tuffanelli DL (1973) Virus-like structures in lymphocytes of patients with systemic and discoid lupus erythematosus. Ann Intern Med 79:396–402

    Google Scholar 

  10. Grimley PM, Schaff Z (1976) Significance of tubulo-reticular inclusions in the pathobiology of human diseases. Pathobiol Annu 6:221–257

    Google Scholar 

  11. Grimley PM, Frantz MM, Michelitch HJ, Decker JL (1973) Abnormal structures in circulating lymphocytes from patients with systemic lupus erythematosus and related diseases. Arthritis Rheum 16:313–323

    Google Scholar 

  12. Grimley PM, Barry DW, Schaff Z (1973) Induction of tubular structures in the endoplasmic reticulum of human lymphoid cells by treatment with 5-bromo-2-deoxyuridine. J Natl Cancer Inst 51:1751–1760

    Google Scholar 

  13. Grimley PM, Davis G, Kang YH, Dooley J, Strohmeyer J, Hoofnagle JH (1983) Tubuloreticular inclusions in peripheral blood mononuclear cells related to systemic alpha interferon. Lab Invest 52:638–649

    Google Scholar 

  14. Grimley PM, Kang YH, Masur H, Frederik W, Hoofnagle JH, Klippel J, Friedman RM (1984) Tubuloreticular inclusions in patients with AIDS: interferon-related effect in circulating T cells and monocytes. In: Friedman-Kien AE, Laubenstein LJ (eds) AIDS: the epidemic of Kaposi's sarcoma and opportunistic infections. Masson, New York, pp 181–192

    Google Scholar 

  15. Grimley PM, Kang YH, Frederik W, Rook AH, Kostianovsky M, Sonnabend JA, Macher AM, Quinnan GV, Friedman RM, Masur H (1984) Interferon-related leukocyte inclusions in acquired immune deficiency syndrome: localization in T cells. Am J Clin Pathol 81:1–12

    Google Scholar 

  16. Györkey F, Sinkovics JG, Györkey P (1971) Electron microscopic observations on structures resembling myxovirus in human sarcomas. Cancer 27:1449–1454

    Google Scholar 

  17. Györkey F, Sinkovics JG, Min KW, Györkey P (1972) A morphologic study on the occurrence and distribution of structures resembling viral nucleocapside in collagen diseases. Am J Med 53:148–158

    Google Scholar 

  18. Györkey F, Sinkovics JG, Györkey P (1982) Tubuloreticular structures in Kaposi's sarcoma. Lancet II:984–985

    Google Scholar 

  19. Hanaoka H, Friedman B (1970) Paired cisternae in human tumor cells. J Ultrastruct Res 32:323–333

    Google Scholar 

  20. Hanissian AS, Hashimoto K (1972) Paramyxovirus-like inclusions in rubella syndrome. J Pediatr 81:231–237

    Google Scholar 

  21. Hanto DW, Frizzera G, Purtilo DT, Sakamoto K, Sullivan JL, Saemundsen AK, Klein G, simenous RL, Najarian JS (1981) Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Esptein-Barr virus. Cancer Res 41:4253–4261

    Google Scholar 

  22. Hanto DW, Frizzera G, Gajl-Peczalska KJ, Sakamoto K, Purtilo DT, Balfour HH, Simmons RL, Najarian JS (1983) Epstein-Barr virus-induced B cell lymphoma after renal transplantation. Acyclovir therapy and transition from polyclonal to monoclonal B cell proliferation. N Engl J Med 306:913–918

    Google Scholar 

  23. Hashimoto K, Chandler RW (1972) Paramyxovirus-like inclusions in systemic lupus erythematosus. Acta Derm Venereol (Stockh) 52:263–277

    Google Scholar 

  24. Helder AW, Feltkamp-Vroom TM (1976) Tubuloreticular structures and anti-nuclear antibodies in autoimmune and non-autoimmune diseases. J Pathol 119:49–56

    Google Scholar 

  25. Helle TL, Britt RH, Colby TV (1984) Primary lymphoma of the central nervous system. Clinicopathological study of experience of Stanford. J Neurosurg 60:94–103

    Google Scholar 

  26. Henry K (1975) Electron microscopy in the non-Hodgkin's lymphomata. Br J Cancer [Suppl 11] 31:73–95

    Google Scholar 

  27. Hochberg FH, Miller DC (1988) Primary central nervous system lymphoma. J Neurosurg 68:835–853

    Google Scholar 

  28. Hochberg FH, Miller G, Schooley RT, Hirsch M, Florine P, Henle W (1983) Central nervous system lymphoma related to Epstein-Barr virus. N Engl J Med 309:745–748

    Google Scholar 

  29. Horváth B, Pena C, Fischer ER (1967) Primary reticulum cell sarcoma (microglioma) of brain. Arch Pathol 87:609–616

    Google Scholar 

  30. Iizuka R, Spalke G (1972) Virus-like structures and crystalline inclusions in primary cerebral reticulosis. Acta Neuropathol (Berl) 21:39–49

    Google Scholar 

  31. Jellinger K, Kothbauer P, Weiss R, Sunder-Plassmann E (1979) Primary malignant lymphoma of the CNS and polyneuropathy in a patient with necrotizing vasculitis treated with immunosuppression. J Neurol 220:259–268

    Google Scholar 

  32. Jenson AB, Spjut HJ, Smith MN, Rapp F (1971) Intracellular branched tubular structures in osteosarcomas. An ultrastructural and serological study. Cancer 27:1440–1448

    Google Scholar 

  33. Kelley RO (1971) Ultrastructural comparisons of paired cisternae in leukemic and mesenchymal cells during mitosis. Anat Rec 171:559–566

    Google Scholar 

  34. Kostianovsky M, Grimley PM (1985) Ultrastructural findings in the acquired immunodeficiency syndrome (AIDS). Ultrastruct Pathol 8:123–130

    Google Scholar 

  35. Kostianovsky M, Kang YH, Grimley PM (1983) Disseminated tubulo-reticular inclusions in acquired immunodeficiency syndrome (AIDS). Ultrastruct Pathol 4:331–336

    Google Scholar 

  36. Kostianovsky M, Grimley PM, Lanoie LO (1985) The presence of acquired immunodeficiency syndrome AIDS-related inclusions in neoplasms, abstracted. Lab Invest 52:36 A

    Google Scholar 

  37. Kostianovsky M, Ornstein JM, Schaff Z, Grimeley PM (1987) Cytomembranous inclusions observed in acquired immunodeficiency syndrome. Arch Pathol Lab Med 111:218–223

    Google Scholar 

  38. Kumanishi T, Washiyama K, Saito T, Nishiyama A, Abe S, Tanaka T (1986) Primary malignant lymphoma of the brain: an immunohistochemical study of eight cases using a panel of monoclonal and heterologous antibodies. Acta Neuropathol (Berl) 71:190–196

    Google Scholar 

  39. Lee S, Harris C, Hirschfeld A, Dickson DW (1988) Cytomembranous inclusions in the brain of a patient with the acquired immunodeficiency syndrome. Acta Neuropathol (Berl) 76:101–106

    Google Scholar 

  40. Lennert K (1981) Histopathologie der Non-Hodgkin-Lymphome (nach der Kiel-Klassifikation). Springer, Berlin Heidelberg New York, pp 145–146

    Google Scholar 

  41. Mirra SS, Check IJ, Porter JD, Cox GW, Miles ML, Weidenheim KM (1981) Rapid evolution of central nervous system lymphoma in renal transplant recipient. Lancet II:868–869

    Google Scholar 

  42. Model LM (1977) Primary reticulum cell sarcoma of the brain in Wiskott-Aldrich syndrome. Arch Neurol 34:633–635

    Google Scholar 

  43. Mollo F, Monga G, Stramignoni A (1971) Electron microscopy in morphological classification of human lymphomas. J Submicrosc Cytol 3:105–120

    Google Scholar 

  44. Moss TH (1986) Tumours of the nervous system: an ultrastructural atlas. Springer, London Berlin Heidelberg New York Paris Tokyo

    Google Scholar 

  45. Murray AB, Büscher H, Erfle V (1983) Intranuclear undulating membranous structures in cells of a human parostal osteosarcoma. Ultrastruct Pathol 5:163–170

    Google Scholar 

  46. Oda H, Mori H, Shibasaki H, Kuroda Y (1974) Unustal tubular structures in brain reticulum cell sarcoma. Lancet II:356–357

    Google Scholar 

  47. Ornstein JM, Simon GL, Kessler CM, Schulof RS (1985) Ultrastructural markers in circulating lymphocytes of subjects at risk for AIDS. Am J Clin Pathol 84:603–609

    Google Scholar 

  48. Pattengale PK, Taylor CR, Panke T, Tatter D, McCormick RA, Rawlinson DG, Davis RL (1979) Selective immunodeficiency and malignant lymphoma of the central nervous system. Acta Neuropathol (Berl) 48:165–169

    Google Scholar 

  49. Popoff NA, Malinin TI (1975) Myxovirus-like particles in cells of American Burkitt's type lymphoma. Acta Neuropathol (Berl) [Suppl] VI:47–52

    Google Scholar 

  50. Purtilo DT (1981) Malignant lymphoproliferative diseases induced by Epstein-Barr virus in immunodeficient patients, including X-linked, cytogenetic and familial syndromes. Cancer Genet Cytogenet 4:251–268

    Google Scholar 

  51. Rich SA (1981) Human lupus inclusions and interferon. Science 213:772–775

    Google Scholar 

  52. Rosenberg NL, Hochberg FH, Miller G, Kleinschmidt-DeMasters BK (1986) Primary central nervous system lymphoma related to Epstein-Barr virus in a patient with acquired immunodeficiency syndrome. Ann Neurol 20:98–102

    Google Scholar 

  53. Saemundsen AK, Purtilo DT, Sakamoto K, Sullivan JL, Synnerholm AC, Hanto D, Simmons R, Anvret M, Collins R, Klein G (1981) Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lympho-proliferative diseases by Epstein-Barr virus complementary RNA/DNA and viral DNA/DNA hybridization. Cancer Res 41:4237–4242

    Google Scholar 

  54. Schaff Z, Lapis K, Sáfrány L (1971) The ultrastructure of primary hepatocellular cancer in man. Virchows Arch [A] 352:340–358

    Google Scholar 

  55. Schaff Z, Heine U, Dalton AJ (1972) Ultramorphological and ultracytochemical studies on tubuloreticular structures in lymphoid cells. Cancer Res 32:2696–2706

    Google Scholar 

  56. Schaff Z, Barry DW, Grimley PM (1973) Cytochemistry of tubulo-reticular structures in lymphocytes from patients with systemic lupus erythematosus and in cultured human lymphoid cells. Lab Invest 29:577–578

    Google Scholar 

  57. Schaff Z, Lapis K, Grimley PM (1976) Undulating membraneous structures associated with the endoplasmic reticulum in tumour cells. Int J Cancer 18:697–702

    Google Scholar 

  58. Schaff Z, Tabor E, Jackson DR, Gerety RJ (1983) AIDS associated ultrastructural changes. Lancet I:1366

    Google Scholar 

  59. Schaff Z, Gerety RJ, Grimley PM, Iwarson SA, Jackson DR, Tabor E (1985) Ultrastructural and cytochemical study of hepatocytes and lymphocytes during experimental non-A, non-B infections in chimpanzees. J Exp Pathol 2:25–35

    Google Scholar 

  60. Shamoto M, Murakami S, Zenke T (1981) Adult T cell leukemia in Japan: an ultrastructural study. Cancer 47:1804–1811

    Google Scholar 

  61. Sidhu GS, Stahl RE, El-Sadr W, Cassai ND, Forrester EM, Zolla-Pazner S (1985) The acquired immunodeficiency syndrome: an ultrastructural study. Human Pathol 16: 377–386

    Google Scholar 

  62. So YT, Beckstead JH, Davis RL (1986) Primary central nervous system lymphoma in acquired immunodeficiency syndrome: a clinical and pathological study. Ann Neurol 20:566–572

    Google Scholar 

  63. Tabuchi K, Nishimoto A (1988) Atlas of brain tumors. Light and electron microscopic features. Springer, Berlin Heidelberg New York Tokyo, pp 215–220

    Google Scholar 

  64. Tovey MG, Dron M, Gresser I (1982) Interferon enhances of Epstein-Barr virus early antigen in Daudi cells. J Gen Virol 60:31–38

    Google Scholar 

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Authors and Affiliations

  1. Department of Neuropathology, National Institute of Neurosurgery, Budapest, Amerikai út 57, H-1426, Budapest, Hungary

    F. Slowik

  2. Ludwig Boltzmann Institut für Klinische Neurobiologie, Krankenhaus Lainz, Wolkersbergenstrasse 1, A-1130, Wien, Austria

    K. Jellinger

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Slowik, F., Jellinger, K. Membranous changes in primary malignant CNS lymphomas. Acta Neuropathol 79, 86–93 (1989). https://doi.org/10.1007/BF00308962

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