Summary
A case is reported of a boy, 3 years of age, with a large medulloepithelioma in the left cerebral hemisphere. Medulloepitheliomas are rare tumors of the primitive medullar epithelium. Histological, immunohistochemical and electron microscopical findings are presented. We discuss previously reported cases, the ontogeny of this type of tumor and the relation to the socalled primitive neuro-ectodermal tumors (PNET).
Similar content being viewed by others
References
Adler R (1971) Ultrastructural changes associated with an invagination phenomenon in embryonic neural aggregates. Exp Cell Res 68:395–403
Auer RN, Becker LE (1983) Cerebral medulloepithelioma with bone, cartilage, and striated muscle. Light and immunohistochemical study. J Neuropathol Exp Neurol 42:256–267
Bailey P, Cushing H (1926) A classification of tumors of the glioma group on a histogenetic basis with a correlated study of prognosis. Lippincott, Philadelphia, pp 26–48, 54–56
Best PV (1974) Posterior fossa medulloepithelioma; report of a case. J Neurol Sci 22: 511–518
Blaauwgeers JLG, Troost D (1988) A midline cerebral primitive neuroectodermal tumor: immunohistochemical evidence for a germinal matrix origin. Clin Neuropathol 7:73–76
Bonnin JM, Rubinstein LJ, Palmer NF, Beckwith JB (1984) The association of embryonal tumors originating in the kidney and brain. A report of seven cases. Cancer 54:2137–2146
Davis TB (1932) Medulloepithelioma of the brain and retina. J Pathol Bacteriol 35:359–366
Deck JHN (1969) Cerebral medulloepithelioma with maturation into ependymal cell and ganglion cells. J Neuropathol Exp Neurol 28:442–454
Fowler M (1986)_Embryonic ependymoma arising in a cerebral hemisphere. Cancer 21:1150–1156
Fujita H, Fujita S (1963) Electronmicroscopic studies on neuroblast differentiation in the central nervous system of domestic fowl. Z. Zellforsch 60:463–478
Fuyita S (1958) Medulloepithelioma: its place in histogenetic classification of neuroectodermal tumors. Acta Pathol Jpn 8 [Suppl]:789–794
Greenfield JG (1934) Two cases of medulloepithelioma (Bailey and Cushing) with special references to the relative malignancy of this type of tumour. J Pathol Bacteriol 38:11–16
Gullotta F, Entzian W (1975) Klinische und morphologische Betrachtungen über das “Medulloepitheliom”. Neurochirurgia (Stuttg) 18:193–199
Herman MM, Sipe JC, Rubinstein LJ, Van den Berg SR, Spence AM, Vraa-Jensen J (1975) An experimental mouse testicular teratoma as a model for neuroepithelial neoplasia and differentiation. II. Electron microscopy. Am J Pathol 81:421–444
Hirano A, Ghatak NR, Zimmerman HM (1973) The fine structure of ependymoblastoma. J Neuropathol Exp Neurol 32: 144–152
Jellinger K (1972) Cerebral medulloepithelioma. Acta Neuropathol (Berl) 22:95–101
Karch SB, Urich H (1972) Medulloepithelioma: definition of an entity. J Neuropathol Exp Neurol 31:27–53
Lolova I, Bojinov S, Ivanova A, Christov V (1972) Cerebral medulloepithelioma, histological and histochemical study of a case. J Neurol Sci 15:173–182
Mabon RT, Svien HJ, Gates EM, Kernohan JW (1950) Medulloepithelioma, a critical re-evaluation. J Neuropathol Exp Neurol 9: 193–197
Pollak A, Friede RL (1977) Fine structure of medulloepithelioma. J Neuropathol Exp Neurol 36:712–725
Russell DS (1960) A note on cerebral medulloepitheliomas. J Pathol Bacteriol 79:403–404
Russell DS, Rubinstein LJ (1989) Pathology of tumours of the nervous system, 5th edn. Edward Arnold, London, pp 250–251
Sato T, Shimoda A, Takahashi T, Daita G, Goto S, Takamura H, Hirama M (1980) Congenital cerebellar tumor with multiple divergent differentiations. Acta Neuropathol (Berl) 50:143–146
Scheithauer BW, Rubinstein LJ (1979) Cerebral medulloepithelioma, report of a case with multiple divergent neuroepithelial differentiation. Child's Brain 5:62–71
Treip CS (1957) A congenital medulloepithelioma of the midbrain. J Pathol Bacteriol 73:357–363
Van den Berg Weerman MA, Dingemans KP (1984) Rapid deparafinization for electron microscopy. Ultrastruct Pathol 7:55–57
Van Epps RR, Samuelson DR, McCormick WF (1967) Cerebral medulloepithelioma, case report. J Neurosurg 27:568–573
Willis RA (1960) The pathology of tumours, 3rd edn. Butterworths, London, pp 957–958
Willis RA (1962) The pathology of tumours of children. Oliver and Boyd, Edingburgh, pp 25–26
Zimmerman HM (1958) Medulloepithelioma (malignant ependymoma). In: American Society of Clinical Pathologists, Seminar on diseases of nervous tissue and muscle. Proceedings of the 24th seminar of the American Society of Clinical Pathologists, Chicago, Am Soc Clin Pathol, Illinois, pp 7–10
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Troost, D., Jansen, G.H. & Dingemans, K.P. Cerebral medulloepithelioma — electron microscopy and immunohistochemistry. Acta Neuropathol 80, 103–107 (1990). https://doi.org/10.1007/BF00294231
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00294231