Skip to main content
Log in

An autopsied case of the Crow-Fukase syndrome: a neuropathological study with emphasis on spinal roots

  • Case Reports
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

An autopsied case of the Crow-Fukase syndrome is reported. Neuropathological findings were as follows: (1) in the sural nerve, there was marked decrease of large and small myelinated fibers. Myelinated fibers showing axonal degeneration and segmental demyelination and remyelination were moderately increased. (2) In the lumbar spinal roots, myelinated fibers showing segmental demyelination and remyelination were frequently observed. The density of myelinated fibers of the ventral root was less at the dural site than the spinal site, while that of the dorsal roots was less at the spinal site than the dural site. (3) In the dorsal root ganglion, there were Nageotte's residual nodules and satellitosis; (4) in the lumbar and thoracic spinal cord, there was pallor of the dorsal column; and (5) nerve cells showing central chromatolysis were frequently observed in the spinal anterior horn cells. Segmental demyelination and remyelination in the spinal roots and loss of myelinated fibers with axonal degeneration in the sural nerve are fibers with axonal degeneration in the sural nerve are main neuropathological features of this syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dyck PJ, Stevens JC, Muder DW, Espinosa RE (1975a) Frequency of nerve fiber degeneration of peripheral motor and sensory neurons in amyotrophic lateral sclerosis. Morphometry of deep and superficial peroneal nerves. Neurology 25:781–785

    Google Scholar 

  2. Dyck PJ, Lais AC, Ohta M, Bastron JA, Okazaki H, Groover RV. (1975b) Chronic inflammatory polyradiculoneuropathy. Mayo Clin Proc 50:621–637

    Google Scholar 

  3. Nakanishi T, Sobue I, Toyokura Y, Nishitani H, Kuroiwa Y, Satoyoshi E, Tsubaki T, Igata A, Ozaki Y (1984) The Crow-Fukase syndrome: a study of 102 cases in Japan. Neurology 34:712–720

    Google Scholar 

  4. Ohnishi A, Hirano A (1981) Uncompacted myelin lamellae in dysglobulinemic neuropathy. J Neurol Sci 51:131–140

    Google Scholar 

  5. Sato Y, Ohnishi A, Tateishi J, Iwashita H, Shii H (1980) The pathology of the peripheral nervous system in two autopsy cases of osteosclerotic myeloma associated with polyneuropathy, skin hyperpigmentation, hypertrichosis and edema. Clin Neurol 20:742–749

    Google Scholar 

  6. Shibasaki H, Ohnishi A, Kuroiwa Y (1982) Use of SEPs to localize degeneration in a rare polyneuropathy: studies on polyneuropathy associated with pigmentation, hypertrichosis, edema, and plasma cell dyscrasia. Ann Neurol 12:355–360

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Umehara, F., Izumo, S., Zyounosono, M. et al. An autopsied case of the Crow-Fukase syndrome: a neuropathological study with emphasis on spinal roots. Acta Neuropathol 80, 563–567 (1990). https://doi.org/10.1007/BF00294621

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00294621

Key words

Navigation