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A comparative immunohistochemical study on striatal Met-enkephalin expression in Alzheimer's disease and in progressive supranuclear palsy

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Summary

Using a sensitive immunoperoxidase technique we examined Met-enkephalin (MEnk) expression in the striatum and globus pallidus external segment (GPe) from patients with Alzheimer's disease (AD) and with progressive supranuclear palsy (PSP). In AD patients strong MEnk-like immunoreactivity was persistent in the striatum showing so-called “striosomes”. In addition, a number of typical “woolly fibers” were observed in the GPe. MEnk-positive striosomes were also visible in the striatum of PSP patients and were similar to those of normal controls and of AD patients. However, the MEnk-positive “woolly fibers” appcarance was less well recognizable in the GPe from all the PSP patients examined.

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Author notes

  1. S. Matsumoto

    Present address: Department of Neurology, Kitano Hospital and Neurological Center, Osaka, Japan

  2. S. Goto

    Present address: Neurophysiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M., Federal Republic of Germany

Authors and Affiliations

  1. Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA

    S. Matsumoto, S. Goto & A. Hirano

Authors
  1. S. Matsumoto
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  2. S. Goto
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  3. A. Hirano
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Matsumoto, S., Goto, S. & Hirano, A. A comparative immunohistochemical study on striatal Met-enkephalin expression in Alzheimer's disease and in progressive supranuclear palsy. Acta Neuropathol 81, 74–77 (1990). https://doi.org/10.1007/BF00662640

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  • DOI: https://doi.org/10.1007/BF00662640

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