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Granular cell brain tumors of the laboratory rat: an immunohistochemical approach

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Summary

We have studied paraffin-embedded specimens of 17 rat granular cell brain tumors (GCBT) from four long-term drug safety carcinogenicity studies by peroxidase-antiperoxidase (PAP) immunohistochemistry with either polyvalent or monoclonal antibodies against glial fibrillary acidic protein (GFAP), S-100 protein (S-100), Leu-7 epitopes, vimentin (VIM), keratin, desmin, and myelin basic protein. We have found that 9 of the 17 GCBT contained GFAP-positive, S-100-positive, and VIM-positive astrocytes, while GFAP-positive and VIM-positive granular cells were observed in 5 of these 9 tumors. Our findings indicate that astroglial cells are involved in rat GCBT and suggest that an astrocytic origin should be considered for these neoplasms.

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Authors and Affiliations

  1. Drug Safety Assessment, Department of Toxicology, 881/403, Sandoz Pharma Ltd., CH-4002, Basle, Switzerland

    E. Perentes, T. Maraziotis & S. R. Qureshi

  2. Department of Neurosurgery, University of Patras School of Medicine, GR-26441, Patras, Greece

    T. Maraziotis

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  1. E. Perentes
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Perentes, E., Maraziotis, T. & Qureshi, S.R. Granular cell brain tumors of the laboratory rat: an immunohistochemical approach. Acta Neuropathol 82, 112–117 (1991). https://doi.org/10.1007/BF00293953

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