Abstract
Polyglucosan bodies (PGBs) in the brain of a 12-year-old Holstein cow exhibiting no signs of neurological abormality were examined by light and electron microscopy and immunohistochemistry. PGBs were disseminated throughout the brain, especially in the pallidum, thalamus and cerebellum. Cow PGBs were found in the neuronal perikaryon and in the neuropil. These were round, slightly to severely basophilic, and were strongly positive for the periodic acid-Schiff reaction. The cow PGBs were immunoreactive for monoclonal antibodies raised against human polyglucosan. Electron microscopic analysis revealed that they were composed of branching filaments, glycogen granules and electrondense meterial. These findings indicate that cow PGBs closely resemble human or canine PGBs in Lafora's disease and PGBs found in aged animals that have been reported previously.
Similar content being viewed by others
References
Gray F, Gherardi R, Marshall A, Jonota I, Poirier J (1988) Adult polyglucosan body disease (APGD). J Neuropathol Exp Neurol 47: 459–474
Hegreberg GA, Padgett GA (1976) Inherited progressive epilepsy of the dog with comparisons to Lafora's disease of man. Fed Proc 35: 1202–1205
Holland JM, Davis WC, Prieur DJ, Collins GH (1970) Lafora's disease in the dog. Am J Pathol 58: 509–529
Kamiya S, Suzuki Y (1989) Polyglucosan bodies in the brain of the cat. J Comp Pathol 101: 263–267
Kamiya S, Suzuki Y, Daigo M (1990) Immunoreactivity of canine and feline polyglucosan bodies for monoclonal antibodies against human polyglucosan. Acta Neuropathol 81: 217–218
Kamiya S, Suzuki Y, Daigo M (1991) Polyglucosan bodies in the central nervous system of a fox. J Comp Pathol 105:467–470
Kreeger JM, Frappier DC, Kendall JD (1990) Systemic glycoproteinosis resembling Lafora's disease in a cow. Cornell Vet 81: 215–221
Lafora GR (1911) Über das Vorkommen amyloider Körperchen im Innern der Ganglionzellen. Virchows Arch [A] 205: 295–303
Robitaille Y, Carpenter S, Karpati G, DiMauro S (1980) A distinct form of adult polyglucosan body disease with massive involvement of central and peripheral neuronal process and astrocytes. Brain 103: 315–336
Suzuki Y, Akiyama K, Suu S (1978) Lafora-like inclusion bodies in the CNS of aged dogs. Acta Neuropathol (Berl) 44: 217–222
Suzuki Y, Ohta K, Kamiya S, Suu S (1980) Topographic distribution pattern of Lafora-like bodies in the spinal cord of some animals. Acta Neuropathol (Berl) 49: 159–161
Yagishita S, Itoh Y, Nakano T, Amano N, Yokoi S, Hasegawa O, Tanaka T (1983) Pleomorphic intra-neuronal polyglucosan bodies mainly restricted to the pallidum. Acta Neuropathol (Berl) 62: 159–163
Yokota T, Ishihara T, Yashida H, Takahashi M, Uchino F, Hamanaka S (1988) Monoclonal antibody against polyglucosan isolated from the myocardium of a patient with Lafora disease. J Neuropathol Exp Neurol 47: 572–577
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yanai, T., Masegi, T., Iwanaka, M. et al. Polyglucosan bodies in the brain of a cow. Acta Neuropathol 88, 75–77 (1994). https://doi.org/10.1007/BF00294362
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00294362