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Central nervous system Hodgkin’s lymphoma without systemic manifestation: case report and review of the literature

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Abstract

A 66-year-old woman treated for ocular myasthenia gravis with azathioprine for 12 years presented with a left fronto-parietal mass. Histology revealed primary Hodgkin’s lymphoma of the central nervous system with CD30, Epstein-Barr virus (EBV) latent membrane protein and CD20-positive, CD45 (LCA)-negative Reed-Sternberg cells surrounded by T cells. Moreover, EBV-encoded RNA-1 (EBER-1) sequences and a monoclonal rearrangement of the immunoglobulin heavy chain CDR2 locus were detected.

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Authors and Affiliations

  1. Department of Neurology, University of Tübingen, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany e-mail: ulrich.herrlinger@uni-tuebingen.de, Tel.: +49-7071-2982141, Fax: +49-7071-295260, , , , , , DE

    U. Herrlinger, A. Melms, J. Dichgans & M. Weller

  2. Department of Neuropathology, University of Tübingen, Tübingen, Germany, , , , , , DE

    R. Meyermann

  3. Department of Molecular Pathology, University of Tübingen, Tübingen, Germany, , , , , , DE

    K. Klingel & R. Kandolf

  4. Department of Pathology, University of Tübingen, Tübingen, Germany, , , , , , DE

    E. Kaiserling

  5. Department of Radiation Oncology, University of Tübingen, Tübingen, Germany, , , , , , DE

    R. D. Kortmann

  6. Department of Neuroradiology, University of Tübingen, Tübingen, Germany, , , , , , DE

    M. Skalej

Authors
  1. U. Herrlinger
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  2. K. Klingel
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  3. R. Meyermann
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  4. R. Kandolf
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  5. E. Kaiserling
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  6. R. D. Kortmann
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  7. A. Melms
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  8. M. Skalej
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  9. J. Dichgans
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  10. M. Weller
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Additional information

Received: 7 May 1999 / Revised, accepted: 16 September 1999

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Herrlinger, U., Klingel, K., Meyermann, R. et al. Central nervous system Hodgkin’s lymphoma without systemic manifestation: case report and review of the literature. Acta Neuropathol 99, 709–714 (2000). https://doi.org/10.1007/s004010051185

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  • DOI: https://doi.org/10.1007/s004010051185

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