Skip to main content
SpringerLink
Log in

HLA-Antigenfrequenzen bei Patienten mit progressiver Sklerodermie und Morphaea

HLA antigen frequencies in patients with progressive systemic sclerosis and morphea

  • Original Works
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Summary

Fortythree patients with progressive systemic sclerosis and 24 patients with morphea are typed for 30 antigens of the HLA-A and B series. There is an increase of the frequency of HLA-B8 in patients with progressive systemic sclerosis (37% vs. 20% in controls: P<0.001, P corr.=n.s.). The increase of the HLA-B8 frequency seems to be most pronounced in patients with a diffuse form of progressive systemic sclerosis. 4 out of 5 patients are HLA-B8 positive (P=0.00672). In patients with acrosclerosis is HLA-B8 only slightly increased (32%), but the increase is greater in male patients (44%) and in patients with an early onset of the disease (36%). With the exception of HLA-A1 there is no deviation of the frequencies of any other HLA antigen tested, especially not of HLA-Aw24. The number of patients with morphea is to small for statistical evaluation.

Zusammenfassung

Bei 43 Patienten mit progressiver Sklerodermie und 24 Patienten mit Morphaea wurden 30 HLA-Antigene der A- und B-Serie bestimmt. Bei Patienten mit progressiver Sklerodermie fand sich mit 37% gegenüber 20% bei Kontrollen eine Vermehrung von HLA-B8 (P<0.001, P corr.=n.s). Am ausgeprägtesten scheint die Frequenzvermehrung von HLA-B8 bei Patienten mit diffuser Form der progressiven Sklerodermie zu sein. 4 von 5 Patienten waren HLA-B8 positiv (P=0,00672). Bei der Akrosklerose fand sich eine frequenzvermehrung von HLA-B8 bei Männern (44%) und Patienten mit ciner frühen Krankheitsmanifestation (36%). Außer HLA-A1 zeigten andere Antigene, insbesondere HLA-Aw24, keine von der Norm abweichende Frequenz. Die Zahl der Patienten mit Morphaea ist für eine statistische Auswertung zu klein.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Betrams, J.: HLA-Antigene und Krankheitsempfänglichkeit. Dtsch. Med. Wschr. 101, 178–184 (1976)

    Google Scholar 

  2. Bertrams, J., Jansen, F. K., Grüneklee, D., Reis, H. E., Drost, H., Beyer, J., Gries, F. K., Kuwert, E.: HLA-antigens and immunoresponsiveness to insulin in insulin-dependent diabetes mellitus. Tiss. Antigens 8, 13–19 (1976)

    Google Scholar 

  3. Birbaum, N. S., Rodnan, G. P., Rabin, B. S., Bassion, S.: Histocompatibility antigens in progressive systemic sclerosis (abstract). 1st Int. Symp. on HLA and Disease, Paris, June 23–25

  4. Clements, P. J., Opelz, G., Terasaki, P. I., Mickey, N. R., Furst, D.: Association of HLA antigen Aw24 with progressive systemic sclerosis (scleroderma). Tiss. Antigens (in press)

  5. Crouzet, J., Marbach, M. C., Camus, J. P., Godeau, P., Heereman, G., Richier, D., Hors, J., Dausset, J.: Recherche d'une association entre antigenes HL-A et sclérodermie systémique. Nouvelle Presse médicale 4, 2489–2492 (1975)

    Google Scholar 

  6. Fog, T., Schuller, E., Jersild, C., Engelfriet, C. P., Bertrams, J.: Myasthenia gravis. In: HLA and Disease, pp. 119–122. (ed.) Dausset, J., Svejgaard, A. Copenhagen/Baltimore: Munksgaard/Williams & Co 1977

    Google Scholar 

  7. Freudenberg, J., Baumann, H., Arnold, W., Berger, J., Meyer zum Büschenfelde, K.-H.: HLA in different forms of chronic active hepatitis. A comparison between adult patients and children. Digestion 15, 260–270 (1977)

    Google Scholar 

  8. Mittal, K. K., Mickey, M. R., Singal, D. P., Terasaki, P. I.: Serotyping for homotransplantation XVIII. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation 6, 913–927 (1968)

    Google Scholar 

  9. Nakawaga, J., Ikehara, Y., Ito, K., Furkase, M.: HLA antigens in varios autoimmune and related diseases (abstract). 1st Int. Symp. on HLA and Disease, Paris, June 23–25

  10. Lobitz, W. C., Civatte, J., Thivolet, J., Betuel, H., Thorsby, E.: Psoriasis. In: HLA and Disease, pp. 127–129. (ed.) Dausset, J., Svejgaard, A.. Copenhagen/Baltimore: Munksgaard/Williams & Co 1977

    Google Scholar 

  11. Ludwig, H., Schernthaner, G., Mayer, W. R.: Inselzellantikörper beim juvenilen Diabetes mellitus. Dtsch. Med. Wschr. 102, 1221–1224 (1977)

    Google Scholar 

  12. Rabin, B. S., Rodnan, G. P., Bassion, S., Gill, T. J.: HL-A antigens in progressive systemic sclerosis (scleroderma). Arthritis Rheum. 18, 381–382 (1975)

    Google Scholar 

  13. Schernthaner, G., Ludwig, H., Mayer, W. R.: Evidence for genetic control of anti-insulin immunity in juvenile onset Diabetes mellitus. Diab. et Metabolisme 3, 117–129 (1977)

    Google Scholar 

  14. Sennekamp, J., Rittner, Ch., Vogel, F., Täuberecht, I.: Verteilung der HLA-Antigene bei Patienten mit Taubenzüchterlunge. Schweiz. Med. Wschr. 108, 315–317 (1978)

    Google Scholar 

  15. Svejgaard, A.: HLA and Disease Registry in Copenhagen (sponsored by WHO). Tissue-Typing Laboratory of the Blood-Grouping Department, Rigshospitalet. Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark

  16. Svejgaard, A., Platz, P., Ryder, L. P.: HL-A and disease associations. A Survey. Transpl. Rev. 22, 1–43 (1975)

    Google Scholar 

  17. Weidner, F., Braun-Falco, O.: Gleichzeitiges Vorkommen von Symptomen der circumscripten und progressiven Sklerodermie. Der Hautarzt 19, 345–350 (1968)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Blutspendedienst des DRK-Landesverbandes Rheinland-Pfalz Bad Kreuznach (Leitender Arzt: Dr. H. Bitz), Burgweg 5-7, D-6550, Bad Kreuznach

    J. Freudenberg

  2. Hautklinik der Johannes Gutenberg-Universität Mainz, Langenbeckstraße 1, D-6500, Mainz, Bundesrepublik Deutschland

    H. Holzmann, S. Schneider & G. W. Korting (Direktor)

Authors
  1. J. Freudenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Holzmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Schneider
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. W. Korting
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Freudenberg, J., Holzmann, H., Schneider, S. et al. HLA-Antigenfrequenzen bei Patienten mit progressiver Sklerodermie und Morphaea. Arch Dermatol Res 263, 197–205 (1978). https://doi.org/10.1007/BF00446441

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00446441

Key words

Schlüsselwörter

Search

Navigation