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Evidence for cell-mediated autoimmunity in patients with pemphigus vulgaris and bullous pemphigoid

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Summary

Lymphoid cells from 4 of 5 patients diagnosed as pemphigus vulgaris (PV) and 6 of 7 patients diagnosed as bullous pemphigoid (BP) demonstrated specific cell-mediated immunity by the production of migration inhibitory factor (MIF) in the presence of autologous epidermal saline extracts. Clinical treatment of these patients with immunosuppressive agents resulted in a state of unresponsivenes of their lymphoid cells to similar concentrations of the antigen. Controls consisted of lymphoid cells from patients with bullous burns or various drug allergies which failed to show significant MIF production in the presence of autologous skin extract. These studies suggest that both PV and BP patients posses cell-mediated immunity (CMI) to their own autologous tissue antigens and this CMI may play a role in the pathogenesis of these diseases.

Zussammenfassung

Der autologe Epidermis-Extrakt löste bei 4 von 5 an Pemphigus vulgaris (PV) und bei 6 von 7 an bullösem Pemphigoid (BP) leidenden patienten eine Leukocytenmigrationshemmung aus. Das auf ähnliche Weise hergestellte Antigen verursachte bei Patienten mit bullöser Verbrennung oder Arzneimittel-Allergie keine Migrationshemmung. Die migrationshemmende Wirkung klang zur Zeit der Symptomfreiheit sichenden erhaltenden Therapie ab. Diese Befunde deuten darauf hin, daß die PV- und die BP-Kranken über gegen epidermale Antigene gerichtete celluläre Autoimmunreaktion verfügen.

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Authors and Affiliations

  1. Department of Dermatology and Venerology, University School of Medicine, P.O. Box 480, H-6701, Szeged, Hungary

    János Hunyadi, Attila Dobozy & Anna Sz. Kenderessy

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  1. János Hunyadi
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  2. Attila Dobozy
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  3. Anna Sz. Kenderessy
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Hunyadi, J., Dobozy, A. & Kenderessy, A.S. Evidence for cell-mediated autoimmunity in patients with pemphigus vulgaris and bullous pemphigoid. Arch. Dermatol. Res. 265, 9–14 (1979). https://doi.org/10.1007/BF00412696

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  • DOI: https://doi.org/10.1007/BF00412696

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