Summary
Pre- and post-operative ovarian cancer patients' sera were examined for the presence or circulating immune complexes using a variety of assay procedures. In contrast to findings with breast cancer patients' sera, sera from patients with other gynaecological tumours or with preclinical disease diagnosed by cytology, no evidence was obtained to indicate that circulating immune complexes were associated with ovarian cancer.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Agnello V, Winchester RJ, Kunkel HG (1970) Precipitin reactions of the Clq component of complement with aggregated γ-globulin and immune complexes in gel diffusion. Immunology 19: 909–919
Baldwin RW, Price MR, Robins RA (1972) Blocking of lymphocyte-mediated cytotoxicity for rat hepatoma cells by tumourspecific antigen-antibody complexes. Nature New Biol 238: 185–187
Baldwin RW, Bowen JG, Price MR (1973) Detection of circulating hepatoma D23 antigen and immune complexes in tumour bearer serum. Br J Cancer 28: 16–24
Baldwin RW, Embleton MJ, Price MR, Vose BM (1974) Embryonic antigen expression on experimental rat tumours. Transplant Rev 20: 77–99
Bowen JG, Baldwin RW (1976) Isolation and characterization of tumour-specific antigen from serum of rats bearing transplanted aminoazo dye-induced hepatomas. Transplantation 21: 213–219
Coggin J, Anderson NG (1974) Cancer differentiation, and embryonic antigens: Some central problems. Adv Cancer Res 19: 106–166
Disaia PJ (1976) Overview of tumor immunology in gynecologic oncology. Cancer 38: 566–580
Evans WH (1976) The liver plasma membrane as a functional mosaic. Biochem Soc Trans 4: 1007–1011
Fletcher DS, Lin TY (1977) Quantitation of immune complexes by competitive inhibition of Clq to insoluble IgG aggregates. J Immunol Meth 15: 39–45
Höffken K, Meredith ID, Robins RA, Baldwin RW, Davies CJ, Blamey RW (1977a) Circulating immune complexes in breast cancer patients. Br Med J 2: 218–220
Höffken K, Price MR, McLaughlin PJ, Moore V, Baldwin RW (1977b) Circulating immune complexes in rats bearing chemically induced tumours. I. Sequential determination during the growth of tumours at various body sites. Int J Cancer 21: 496–504
Höffken K, Meredith ID, Robins RA, Baldwin RW, Davies CJ, Blamey RW (1978a) Immune complexes and prognosis of human breast cancer. Lancet 1: 672
Höffken K, Price MR, Moore V, Baldwin RW (1978b) Circulating immune complexes in rats bearing chemically-induced tumours: II. Characterisation of sera from different stages of tumour growth. Int J Cancer 22: 576
Lancet (Editorial) (1977) Immune complexes in health and disease. Lancet 1: 580
Nicolson GL, Poste G (1976a) The cancer cell: Dynamic aspects and modifications in cell-surface organization (Part 2). New Engl J Med 295: 253–258
Nicolson GL, Poste G (1976b) The cancer cell: dynamic aspects and modifications in cell-surface organization (Part 1). New Engl J Med 295: 197–203
Papsidero LD, Harvey SR, Snyderman MC, Nemoto T, Valenzuela L, Chu TM (1978) Characterization of immune complexes from the pleural effusion of a breast cancer patients. Int J Cancer 21: 675–682
Poulton TA, Crowther ME, Hay FC, Nineham LJ (1978) Immune complexes in ovarian cancer. Lancet 2: 72
Price MR, Baldwin RW (1977) Shedding of tumor cell surface antigens. In: Poste G, Nicolson GL (eds) Dynamic aspects of cell surface organization. Cell surface reviews, vol 3. North Holland, Amsterdam, p 423–471
Price MR, Robins RA (1978) Circulating factors modifying cell-mediated immunity in experimental neoplasia. In: Castro JE (ed) Immunological aspects of cancer. MTP Press, Lancaster, p 155–181
Rees RC, Price MR, Baldwin RW (1979) Expression of oncodevelopmental antigens in chemical carcinogenesis. In: Busch H (ed) Methods in cancer research, vol 15. Academic Press, New York (in press), pp 99–133
Robins RA, Baldwin RW (1977) Immune markers on cancer cells. Cancer Immunol Immunotherap 2: 205–209
Robins RA, Baldwin RW (1978) Immune complexes in cancer. Cancer Immunol Immunother 4: 1–3
Rossen RD, Reisberg MA, Hersh EM, Gutterman JU (1977) The Clq binding test for soluble immune complexes: clinical correlations obtained in patients with cancer. J Natl Cancer Inst 58: 1205–1215
Sjögren HO, Hellström I, Bansal SC, Hellström KE (1971) Suggestive evidence that the “blocking antibodies” of tumor bearing individuals may be antigen-antibody complexes. Proc Natl Acad Sci 68: 1372–1375
Teshima H, Wanebo H, Pinsky C, Day NK (1977) Circulating immune complexes detected by the125I-Clq deviation test in sera of cancer patients. J Clin Invest 59: 1134–1142
Theofilopoulos AN, Wilson CB, Dixon FJ (1976) The Raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest 57: 169–182
Theofilopoulos AN, Andrews BS, Urist MH, Morton DL, Dixon FJ (1977) The nature of immune complexes in human cancer sera. J Immunol 119: 657–663
Wisher MH, Evans WH (1975) Functional polarity of the rat hepatocyte surface membrane. Biochem J 146: 375–388
Yamada K (1978) Cell surface marker for malignancy. Nature (Lond) 273: 335
Zubler RH, Lambert PH (1976) The125I-Clq binding test for the detection of soluble immune complexes. In: Bloom BR, Davids JR (eds) In vitro methods in cell-mediated and tumour immunity. Academic Press, New York, pp 565–572
Author information
Authors and Affiliations
Additional information
These studies were supported by the Cancer Research Campaign
Rights and permissions
About this article
Cite this article
Price, M.R., McLaughlin, P.J., Robins, R.A. et al. Tumour markers with unknown functions in gynaecological neoplasia. Arch. Gynecol. 229, 325–331 (1980). https://doi.org/10.1007/BF02108583
Issue Date:
DOI: https://doi.org/10.1007/BF02108583