Abstract
Four out of 42 cases of primary tubal malignancy diagnosed in our histopathological laboratory were malignant mixed Müllerian tumors (MMMT). All four patients were postmenopausal with a mean age of 66.5 years at diagnosis. A correct preoperative diagnosis was made only in one case. Tumor staging (FIGO) revealed stage Ila, IIIc and IV. One patient died of postoperative pulmonary embolism, a second patient of an unknown cause five month after surgery and a third patient died of disease after I I months with secondary deposits in pelvic peritoneum, omentum and paraaortic lymph nodes. The fourth patient is still alive. One patient received chemotherapy alone, one by radiation and chemotherapy and two patients by radiation alone. Tumor spread at the time of diagnosis and the residual tumor volume were the most important prognostic factors. All tumors were histologically the homologous type of MMMT (carcinosarcomas). No heterologous elements were found. Metastatic tumors showed only sarcomatous elements.
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Literatur
Acosta AA, Kaplan AL, Kaufmann RH (1974) Mixed Müllerian tumors of the oviduct. Obstet Gynecol 44:84–90
Barabat RR, Rubin SC, Saigo PE, Chapman D, Lewis JL, Jones WB, Hakes TB, Markman M, Reichman B, Hoskins W (1991) Cisplatin-based combination chemotherapy of the Fallopian tube. Gynecol Oncol 42:156–160
Barabat RR, Rubin SC, Saigo PE, Lewis JL, Jones WB, Curtin JP (1993) Second-look laparotomy in carcinoma of the Fallopian tube. Obstet Gynecol 82:748–751
Böhme M, Donat H, Baumann D (1992) Das primäre Tubenkarzinom. Zentbl Gynakol 114:244–248
Carlson JA, Ackerman BL, Wheeler JE (1993) Malignant mixed Mullerian tumor of the Fallopian tube. Cancer 71:187–192
Chang HC, Hsueh S, Soong YK (1991) Malignant mixed Mnllerian tumor of the Fallopian tube. Case report and review of the literature. Chang Keng I Hsueh 114:259–263
Chiou YK, Su IJ, Chen CA, Hsieh CY (1991) Malignant mixed Mnllerian tumor of the Fallopian tube. J Formos Med Assoc 90:793–795
Cordell JL, Falin B, Erber W (1984) Immunoenzymatic labelling of monoclonal antibodies using immune complex of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP). J Histochem Cytochem 32:219–222
Deppe G, Zbella E, Friberg J, Thomas W (1984) Combination chemotherapy for mixed Mnllerian tumor of the Fallopian tube. Cancer 54:1517–1520
Erez S, Kaplan AL, Wall JA (1967) Clinical staging of carcinoma of the uterine tube. Obstet Gynecol 30:547–550
Frigerio L, Pirondini A, Pileri M, Pifarotti G, Busci L, Rabaiotti E, Ferrari A (1993) Primary carcinoma of the Fallopian tube. Tumori 79:40–44
Hanjani P, Petersen RO, Bonell SA (1980) Malignant mixed Müllerian tumor of the Fallopian tube: report of a case and review of literature. Gynecol Oncol 9:381–393
Imachi M, Tsukamoto N, Shigematsu T, Watanabe T, Uehira K, Amada S, Umezu T, Nakano H (1992) Malignant mixed Müllerian tumor of the Fallopian tube: report of two cases and review of the literature. Gynecol Oncol 47:114–124
Kaya S, Grillo M, Gent H-J (1992) Therapie des priml aren Tubenkarzinoms — eine retrospektive Studie über 30 Fälle. Zentbl Gynäkol 114:254–325
King A, Seraj IM, Thrasher T, Slater J, Wagner RJ (1989) Fallopian tube carcinoma: a clinicopathological study of 17 cases. Gynecol Oncol 33:351–355
Kohorn EI, Schwartz PE, Chambers JT, Peschel A, Kapp DS, Merino M (1986) Adjuvant therapy in mixed Müllerian tumors of the uterus. Gynecol Oncol 23:212–221
Meis JM, Lawrence WD (1990) The immunohistochemical profile of malignant mixed Müllerian tumor. Overlap with endometrial adenocarcinoma. Am J Clin Pathol 94:1–7
Muntz HG (1989) Carcinosarcomas and mixed Müllerian tumors of the Fallopian tube. Gynecol Oncol 34:109–115
Pfeiffer P, Mogensen H, Amtrup F, Honore E (1989) Primary carcinoma of the Fallopian tube. A retrospektive study of patients reported to the Danish cancer registry in a five year period. Acta Oncol 28:7–11
Poulsen HE, Taylor CW, Sobin LH (1975) International histological classification of tumors. No. 13. Histological typing of female genital tract tumors. World Health Organization, Geneva, p 69
Rosen A, Klein M, Lahousen M, Graf AH, Rainer A, Vavra N (1993) Primary carcinoma of the Fallopian tube — a retrospective analysis of 115 patients. Austrian Cooperative Study Group for Fallopian Tube Carcinoma. Br J Cancer 68:605–609
Schink JC, Lurain JR (1991) Rare gynecologic malignancies. Curr Opin Obstet Gynecol 3:78–90
Weber AM, Hewett WF, Gajewski WH, Curry SL (1993) Malignant mixed Müllerian Tumors of the Fallopian tube. Gynecol Oncol 50:239–243
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Horn, L.C., Werschnik, C., Bilek, K. et al. Diagnosis and clinical management in malignant Müllerian tumors of the fallopian tube. Arch Gynecol Obstet 258, 47–53 (1996). https://doi.org/10.1007/BF01370932
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DOI: https://doi.org/10.1007/BF01370932