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Homozygous factor V Leiden mutation in a woman with multiple adverse pregnancy outcomes

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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract 

We report a case with one intrauterine fetal death (IUFD) at 32 weeks of gestation, one premature delivery at the same week, and one abortion of unknown etiology at 12 weeks of gestation. We discuss that the presence of homozygosity for Factor V Leiden may be associated with placental insufficiency in this woman. Application of anticoagulant therapy may have been beneficial in her current pregnancy.

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, University of Goettingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany, , , , , , DE

    H.-U. Pauer & B. Hinney

  2. Institute of Human Genetics, University of Goettingen, Germany, , , , , , DE

    J. Neesen & M. Schloesser

  3. Department of Gynecology and Obstetrics, Albert Schweitzer Hospital, Northeim, Germany, , , , , , DE

    R. Rauskolb

Authors
  1. H.-U. Pauer
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  2. J. Neesen
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  3. M. Schloesser
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  4. B. Hinney
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  5. R. Rauskolb
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Additional information

Received: 1 February 2000 / Accepted: 9 May 2000

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Pauer, HU., Neesen, J., Schloesser, M. et al. Homozygous factor V Leiden mutation in a woman with multiple adverse pregnancy outcomes. Arch Gynecol Obstet 264, 164–165 (2000). https://doi.org/10.1007/s004040000095

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  • DOI: https://doi.org/10.1007/s004040000095

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