Summary
We investigated the effects of blood pressure on the blood flow in the inner ear as compared with other organs in normotensive rats (NR), spontaneously hypertensive rats (SHR) and renal hypertensive rats (RHR). The cardiac output and the regional blood flow were measured by a radioactive microsphere technique in conscious rats. The haemodynamics of the inner ear and other organs and the effects of a converting-enzyme inhibitor (SA-446) on the regional blood flow were compared among NR, SHR, and RHR, the blood pressure being 107, 152, and 185 mm Hg, respectively. With the exception of the heart, the organ blood flow was lower in SHR than in NR in all organs, including the inner ear. It was also lower in RHR than in SHR. The blood pressure dropped after i.v. injection of SA-446, while the regional blood flow increased. The effect was strongest in RHR, followed by SHR and finally NR.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abe Y, Jackson RT (1972) The use of labeled microspheres to determine blood flow in the dog's nasal mucosa. Ann Otol Rhinol Laryngol 81: 82–86
Abe Y, Takada T, Miura K, Yamamoto K (1981) Cardiac output and blood flow distribution in normotensive and hypertensive rats. Eighth Internationals Congress of Pharmacology (Tokyo) July, 19–14, 1981
Angelborg C, Hultcrantz E, Åerup B (1977) The cochlear blood flow. Acta Otolaryngol (Stockh) 83: 92–917
Ferrone RA, Walsh GM, Tsutiya M, Flohlich ED (1979) Comparison of hemodynamics in conscious spontaneous and renal hypertensive rat. Am J Physiol 236: H403-H408
Gavras H, Brunner HR, Thurston H, Laragh JH (1975) Reciprocation of renin dependency with sodium volume dependency in renal hypertension. Science 188: 1316–1317
Hiley CR, Yates MS (1978) The distribution of cardiac output in the anesthetized spontaneous hypertensive rats. Clin Sci 55: 317–320
Hultcrantz E, Larsen HC, Angelborg C (1980) Effects of CO2 inhalation on cochlear blood circulation. ORL J Otorhinolaryngol Relat Spec 42: 304–312
Hultcrantz E, Hillerdal M, Angelborg C (1982) Effect of nicotinic acid on cochlear blood flow. Arch Otorhinolarnygol (NY) 234: 151–155
Iso T, Yamauchi H, Suda H, Nakata K, Nishimura K, Iwao J (1981) A new potent inhibitor of converting enzyme: (2R, 4R)-2-(2-hydroxyphenyl)-3-(3-mercaptopropyonyl)-4-thiazolidinecar-boxylic acid (SA-446). Jpn J Pharmacol 31: 875–882
Larsen HC (1982) The effect of intracranial hypertension on cochlear blood flow. Acta Otolarnygol (Stockh) 93: 415–419
Larsen HC, Angelborg C, Hultcrantz E (1982) Cochlear blood flow related to hyperosmotic solutions. Arch Otorhinolaryngol (NY) 234: 145–150
Lawrence M, Clapper MP (1972) Analysis of flow pattern in vas spirale. Acta Otolarnygol (Stockh) 73: 94–103
Morimitsu T, Matsuo K, Suga F (1965) Behaviour of the cochlear blood flow. Ann Otol Rhinol Laryngol 74: 22–32
Perlman HB, Kimura R (1962) Cochlear blood flow in acoustic trauma. Acta Otolarnygol (Stockh) 54: 99–110
Rudorph AM, Heyman MA (1967) The circulation of the fetus in utero: Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 21: 163–184
Suga F, Snow JB (1969) Adrenergic control of cochlear blood flow. Ann Otol Rhinol Laryngol 78: 358–374
Tsutiya M, Ferrone RA, Walsh GM, Flohlic ED (1978) Regional blood flow measured in conscious rats by combined Fick and microsphere methods. Am J Physiol 235: H357-H360
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sugiyama, M., ¯Ohashi, K., Sasaki, T. et al. The effect of blood pressure on inner ear blood flow. Arch Otorhinolaryngol 239, 197–203 (1984). https://doi.org/10.1007/BF00464244
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00464244