Summary
The effects of lidocaine in doses of 2.0–6.0 mg/kg with intravenous injection on optokinetic nystagmus were observed in 21 rabbits. No effect of lidocaine was obtained on the frequency of OKN. On the other hand, the amplitude of OKN in lidocaine groups decreased after the injection. The mode and place of the action of lidocaine on OKN were discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bernhard, C. G., Bohm, E.: On the central effects of xylocaine with special reference to its influence on epileptic phenomena. Acta Physiol. Scand.31, Suppl. 114, 5–6 (1954)
Bernhard, C. G., Bohm, E.: The action of local anesthetics on experimental epilepsy in cats and monkeys. Brit. J. Pharmacol.10, 288–295 (1955)
Bochenek, Z., Makowiecka, R.: Behaviour of spontaneous vestibular nystagmus after xylocaine administration. Otolaryng. Pol.23, 151–159 (1969). Excerpta Medica, Section II,23, 173 (1970)
Crawford, O. B.: Comparative qualities of three new local anesthetic drugs: xylocaine, cyclaine, and pravocaine. Anesthesiol.14, 278–290 (1953)
Davidoff, R. A., Atkin, A., Anderson, P. J., Bender, M. B.: Optokinetic nystagmus and cerebral disease. Arch. Neurol. (Chic.)14, 73–81 (1966)
Gejrot, T.: The influence of xylocaine on induced and spontaneous nystagmus. Pract. oto-rhino-laryng.25, 361–366 (1963)
Gardner, R., Weitzman, E. D.: Examination for optokinetic nystagmus in sleep and waking. Arch. Neurol. (Chic.)16, 415–420 (1967)
Ito, I.: Electroencephalographic studies on anticonvulsants. J. Yonago Med. Ass. (Yonago, Japan)9, 644–660 (1958)
Nouri, M. E.: Die Differentialdiagnose des Spontannystagmus. Mschr. Ohrenheilk. (Wien)107, 251–255 (1973)
Sawada, K.: Electroencephalographic studies on mechanisms of adapting to optic stimulation. J. Otolaryng. (Tokyo)71, 777–795 (1968)
Shirabe, S.: Nytagmographische Registrierung des rotatorischen und optokinetischen Nystagmus beim Meerschweinchen und seine Beeinflussung durch Streptomycinsulfat und Dimorpholamin. Arch. klin. exp. Ohr.-, Nas.- u. Kehlk.-Heilk.198, 206–214 (1971)
Tanaka, K., Yasukata, M., Otsubo, Z.: Actions of procaine on the central nervous system of rabbits. Jap. J. Pharmacol.5, 42–47 (1955)
Tibbling, L.: Observations on central mechanisms common to vestibular and optokinetic nystagmus. Acta Otolaryng. (Stockh.)69, 434–442 (1970)
Takakura, T., Mizukoshi, K., Nagaba, M., Ishikawa, K., Honda, H., Ino, H.: On the influence of the several drugs upon the optokinetic nystagmus. Equilibrium Res. (Japan)29, 59–60 (1971)
Waldecker, G.: Über die Wirkung von Phenothiazinen und Dolantin auf den Nystagmus. Arch. Ohr.-, Nas.- u. Kehlk.-Heilk.174, 486–495 (1960)
Yasuda, K.: The effect of intravenous injection of xylocaine on vertigo. Otologia Fukuoka (Fukuoka, Japan)19, 405–410 (1973)
Author information
Authors and Affiliations
Additional information
The author thanks Dr. N. Reicke for his kind help in the performance of this study.
Rights and permissions
About this article
Cite this article
Tokunaga, O. The influence of intravenous injection of lidocaine on optokinetic nystagmus in rabbits. Arch Otorhinolaryngol 217, 139–145 (1977). https://doi.org/10.1007/BF00665533
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00665533