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Organ of Corti-specific polypeptides: OCP-I and OCP-II

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Summary

Two polypeptides, OCP-I and OCP-II, specific to the organ of Corti of the guinea pig and the rat, were detected by two-dimensional polyacrylamide gel electrophoresis. They were neither present in other inner ear structures, nor in other organs tested. The two polypeptides constitute a substantial portion of the total protein of the organ of Corti. Both inner and outer layer of the organ of Corti contained approximately equal amounts of OCP-I and OCP-II. The molecular weights of OCP-I and OCP-II are 37,000 and 22,500 daltons, respectively. The corresponding pI values are 4.9 and 5.1, respectively. In addition, actin and tubulin were detected in both layers of the organ of Corti.

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Authors and Affiliations

  1. Departments of Otolaryngology, Psychiatry, and Dental Basic Sciences, Washington University, Schools of Medicine and Dental Medicine, 63110, St. Louis, MO, USA

    I. Thalmann, H. L. Rosenthal, B. W. Moore & R. Thalmann

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  1. I. Thalmann
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  2. H. L. Rosenthal
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  3. B. W. Moore
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  4. R. Thalmann
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Additional information

Supported by NIH grants NS 06575 (R.T.), NS 05270 (B.W.M.)

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Thalmann, I., Rosenthal, H.L., Moore, B.W. et al. Organ of Corti-specific polypeptides: OCP-I and OCP-II. Arch Otorhinolaryngol 226, 123–128 (1980). https://doi.org/10.1007/BF00455126

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  • DOI: https://doi.org/10.1007/BF00455126

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