Die Kombinationsbehandlung mit Chemo-Strahlentherapie maligner Tumoren unter Berücksichtigung eines Zeitfaktors

Summary

In a 8-year period 102 patients with advanced inoperable head and neck tumors and recurrences were treated with irradiation after so called partial synchronization with chemotherapy. During the first 2 years only 5FU was used for chemotherapy; later on the highly differentiated keratinizing squamous cell carcinomas were treated with bleomycin. For the other malignant neoplasias we used 5FU and adriamycin, preferring the latter. This chemotherapy followed by irradiation was tolerated with minimal complications and insignificant side effects. The breakdown of survival rates according to the tumor localization showed the best 5-year survival rates of patients with laryngeal/hypopharyngeal carcinomas (advanced tumors or recurrences, respectively). Thus, combined therapies seem to lead to a prolongation of life of reasonable quality and are hence a useful supplement to the therapeutical methods for advanced ENT malignant tumors.