Abstract
Lipid peroxidation induced by heavy ion irradiation was investigated in 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) liposomes. Lipid peroxidation was induced using accelerated heavy ions that exhibit linear energy transfer (LET) values between 30 and 15 000 keV/μm and doses up to 100 kGy. With increasing LET, the formation of lipid peroxidation products such as conjugated dienes, lipid hydroperoxides, and thiobarbituric acid-reactive substances decreased. When comparing differential absorption spectra and membrane fluidity following irradiation with heavy ions and x-rays (3 Gy/min), respectively, it is obvious that there are significant differences between the influences of densely and sparsely ionizing radiation on liposomal membranes. Indications for lipid fragmentation could be detected after heavy ion irradiation.
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Received: 6 March 1997 / Accepted in revised form: 31 March 1998
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Ziegler, C., Wessels, J. Investigation of lipid peroxidation in liposomes induced by heavy ion irradiation. Radiat Environ Biophys 37, 95–100 (1998). https://doi.org/10.1007/s004110050100
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DOI: https://doi.org/10.1007/s004110050100