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Detection of methadone in human hair by gas chromatography/mass spectrometry

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Summary

Determination of methadone in human hair by gas chromatography/mass spectrometry was described. Helium as carrier gas, a 30-m bonded phasefused silica DB-1 capillary column and splitless injection at 230°C temperature were used. The concentrations of methadone and its metabolites were measured in addition by radioimmunoassay (RIA). Both methods GC/MS and RIA showed the presence of methadone in human hair.

Zusammenfassung

In dieser Arbeit wurde die Bestimmung von Methadon in menschlichen Haaren mittels Gaschromatographie/Massenspektrometrie (GC/MS) beschrieben. Als Trägergas wurde Helium benützt; die Säule war eine Kapillarsäule DB-1 un die Injektion eine Splitlos-Injektion, bei einer Verdampfungstemperatur von 230°C. Die Methadonkonzentrationen in den Haaren wurden auch mittels Radioimmunoassay (RIA) durchgeführt. Beide Methoden GC/MS und RIA zeigen das Vorhandensein des Methadons im menschlichen Haar.

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References

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Authors and Affiliations

  1. Department of Forensic Medicine, University of Ulm, Prittwitzstrasse 6, D-7900, Ulm, Federal Republic of Germany

    S. Balabanova

  2. Pharmakin GmbH, Graf-Arco-Strasse 3, D-7900, Ulm, Federal Republic of Germany

    P. J. Arnold & V. Luckow

  3. Department of Pharmacology, University of Ulm, Oberer Eselsberg, D-7900, Ulm, Federal Republic of Germany

    H. Brunner & H. U. Wolf

Authors
  1. S. Balabanova
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  2. P. J. Arnold
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  3. H. Brunner
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  4. V. Luckow
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  5. H. U. Wolf
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Balabanova, S., Arnold, P.J., Brunner, H. et al. Detection of methadone in human hair by gas chromatography/mass spectrometry. Z Rechtsmed 102, 495–501 (1989). https://doi.org/10.1007/BF00200647

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  • DOI: https://doi.org/10.1007/BF00200647

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