Summary
High-performance liquid chromatography was employed to determine the concentration of thiopental in body fluids and tissues in an individual who had died due to intravenous injection of the clinical dose. The blood concentration of thiopental was 0.6 mg/l. Among the 10 tissues examined, the brain and thymus showed the highest level of the drug; 11.9 mg/kg and 7.66 mg/kg, respectively. The results are discussed in the light of the relevant literature.
Zusammenfassung
Zur Bestimmung von Thiopental in Körperflüssigkeiten und Geweben einer Person, welche aufgrund einer intravenösen Injektion einer klinischen Dosis verstarb, wurde mit Hilfe der Hochdruckflüssig-keitschromatographie bestimmt. Die Blutkonzentration von Thiopental war 0,6 mg/l. Unter den 10 Geweben, welche untersucht wurden, zeigten Hirn und Thymus die höchsten Spiegel des Medikaments, nämlich 11,9 mg/kg bzw. 7,66 mg/kg. Die Resultate werden unter Berücksichtigung der Literatur diskutiert.
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References
Costantino AG, Caplan YH, Levine BS, Dixon AM, Smialek JE (1990) Thiamylal: review of the literature and report of a suicide. J Forensic Sci 35:89–96
Thompson DS, Eason CN, Flacke JW (1973) Thiamylal anaphylaxia. Anesthesiology 39:556–558
Clarke RSJ, Dundee JW, Garrett RT, McArdle GK, Sutton JA (1975) Adverse reactions to intravenous anaesthetics. Br J Anaesth 47:575–585
Kudo K, Nagata T, Kimura K, Uehori R, Noda M (1988) Toxicological analysis of thiamylal in biological materials by gas chromatography/mass spectrometry. Forensic Sci Int 37:193–200
Blackman GL, Jordan GJ, Paull JD (1978) Analysis of thiopentone in human plasma by high-performance liquid chromatography. J Chromatogr 145:492–495
Toner W, Howard PJ, Dundee JW, McIlroy PDA (1979) Estimation of plasma thiopentone. Anaesthesia 34:657–660
Kelner M, Bailey DN (1983) Reversed-phase liquid-chromatographic simultaneous analysis for thiopental and pentobarbital in serum. Clin Chem 29:1097–1100
Yashiki M (1977) Toxicological study on intravenous thiopental anesthesia. Jpn J Leg Med 31:191–195 (in Japanese with English summary)
Pharmaceutical Society of Japan (1992) Standard methods of chemical analysis in poisoning — with commentary —, 4th edn. Nanzando, Tokyo (in Japanese)
Fernando GCA (1990) A suicide by thiopentone infusion. Am J Forensic Med Pathol 11: 309–311
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This study was supported in part by a grant from the Shimabara Science Promotion Foundation to T. Y. and by Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan to K. K. (04152052), T. Y. (04836007) and D. N. (04770356)
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Yasudal, T., Yamaba, T., Sawazakil, K. et al. Postmortem concentrations of thiopental in tissues: A sudden death case. Int J Leg Med 105, 239–241 (1993). https://doi.org/10.1007/BF01642801
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DOI: https://doi.org/10.1007/BF01642801