Summary
Positive electron impact (EI), positive chemical ionization (CI), and negative CI mass spectra of 14 benzophenones are presented. In the positive EI mode, intense molecular peaks appeared for most compounds; some other peaks due to splitting at both sides of the carbonyl group also appeared. In the positive CI mode, [M+1]+ quasi-molecular ions together with [M+C2H5]+ peaks were observed for all compounds; some fragment peaks were common to those in the positive EI mode. In the negative CI mode, the spectra were much simpler than those in the positive EI or CI mode. In the 1 Torr negative CI mode, some spectra showed only single molecular anions; in the 0.01 Torr negative CI mode, halogen or nitro peaks appeared in addition to the molecular anions. An extraction procedure for benzophenones from human urine and plasma after heating in strong acid, and their separation by gas chromatography (GC) are also presented to serve for their actual identification by GC/mass spectrometry.
Zusammenfassung
Es werden positive Elektronenstoß-(EI)-, positive chemische Ionisierungs-(CI)- und negative CI-Massenspektren von Benzophenonderivaten beschrieben. Beim positiven EI-Modus wurden bei fast allen Verbindungen intensive Molekülpeaks beobachtet; andere Peaks entstehen durch Spaltungsreaktionen beiderseits der Carbonylgruppe. Beim positiven CI-Modus erschienen quasi-molekulare Ionen [M+1]+ zusammen mit [M+C2H5]-Peaks bei fast allen Verbindungen; einige Fragmentierungsionen entsprachen denen des positiven EI-Modus. Beim negativen CI-Modus waren die Spektren viel einfacher als beim positiven EI- oder CI-Modus. Im Falle des 1 Torr negativen CI-Modus zeigten einige Spektren lediglich einzelne Molekül-Anionen; beim 0,01 Torr negativen CI-Modus erschienen Halogen-oder Nitro-Peaks zusätzlich zu den Molekül-Anionen. Weiterhin wird ein Extraktionsverfahren zur Isolierung der Benzophenone aus Urin und Plasma nach stark saurer Hydrolyse beschrieben sowie die Trennung mittels Gas-Chromatographie (GC) als Vorbereitung zur Identifizierung durch GC/Massenspektrometrie.
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Suzuki, O., Hattori, H., Asano, M. et al. Positive and negative ion mass spectrometry of benzophenones, the acid-hydrolysis products of benzodiazepines. Z Rechtsmed 98, 1–10 (1987). https://doi.org/10.1007/BF00200380
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DOI: https://doi.org/10.1007/BF00200380
Key words
- Benzophenones, mass spectrometry
- Mass spectrometry, negative ion chemical ionization
- Benzodiazepines, mass spectrometry