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Diffusion of fluorescein in the corneal stroma

  • Session III: Clinical Applications
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Abstract

Movement of fluorescein in the eye was simulated on the basis of a multiple-compartment model, in which the cornea was divided into a series of cylindrical sleeves to allow 3-dimensional diffusion of fluorescein with rapid exchange at the limbus. If the dye was administered into the central 5 mm of the cornea, the loss at the limbus was found to be negligible in the early period but it became considerable later. The effect of fluorescein exchange at the limbus on the calculations of the dye transfer coefficients was estimated. Systematic errors in the fluorophotometric measurement of aqueous humor flow are discussed.

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References

  • Bloom JN, Levene RZ, Thomas G, Kimura R (1976) Fluorophotometry and the rate of aqueous flow in man. I. Instrumentation and normal values. Arch Ophthalmol 94:435

    PubMed  Google Scholar 

  • Coakes RL, Brubaker RF (1979) Method of measuring aqueous humor flow and corneal endothelial permeability using a fluorophotometry nomogram. Invest Ophthalmol Vis Sci 18:288

    PubMed  Google Scholar 

  • Goldmann H (1950) Über fluorescein in der menschlichen Vorderkammer. Das Kammerwasser-Minutenvolumen des Menschen. Ophthalmologica 120:65

    Google Scholar 

  • Jones RF, Maurice DM (1966) New methods of measuring the rate of aqueous humor flow in man with fluorescein. Exp Eye Res 5:209

    Google Scholar 

  • Nagataki S (1975) Aqueous humor dynamics of human eyes as studied using fluorescein. Jpn J Ophthalmol 19:235

    Google Scholar 

  • Ota Y, Mishima S, Maurice DM (1974) Endothelial permeability of the living cornea to fluorescein. Invest Ophthalmol 13:945

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA

    F. Brubaker & A. Grotte

  2. Department of Ophthalmology, School of Medicine, University of Tokyo, Tokyo, Japan

    S. Nagataki

Authors
  1. S. Nagataki
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  2. F. Brubaker
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  3. A. Grotte
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Additional information

Supported by NIH Grant EYOO634 and the Mayo Foundation

Research to Prevent Blindness International Research Scholar

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Nagataki, S., Brubaker, F. & Grotte, A. Diffusion of fluorescein in the corneal stroma. Graefe's Arch Clin Exp Ophthalmol 222, 256–258 (1985). https://doi.org/10.1007/BF02133692

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  • DOI: https://doi.org/10.1007/BF02133692

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