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Localization of nitric oxide synthase immunoreactivity in mast cells of human nasal mucosa

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Abstract

Nitric oxide (NO)-synthase immunoreactivity has been detected for the first time in mast cells of human normal nasal mucosa, with an antibody specific for neuronal NO-synthase. Intense immunoreactivity was revealed in secretion granules of mast cells but was found in mast cell granules free in the extracellular matrix only in some instances; no reactivity was found in the cytoplasm of this or other cell types. These findings suggest that human nasal mast cells contain a particulate isoform of NO-synthase, which shares epitopes with neuronal NO-synthase and is rapidly removed from granules upon exocytosis.

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Authors and Affiliations

  1. Department of Human Anatomy and Histology, Section “E. Allara”, University of Florence, Viale G. Pieraccini 6, I-50139, Florence, Italy

    S. Bacci, R. Arbi-Riccardi & M. B. Borghi-Cirri

  2. Institute of Pharmacology and Toxicology, University of Graz, Austria

    B. Mayer

  3. Karl Zeiss, Milan, Italy

    C. Rumio

Authors
  1. S. Bacci
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  2. R. Arbi-Riccardi
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  3. M. B. Borghi-Cirri
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  4. B. Mayer
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  5. C. Rumio
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Bacci, S., Arbi-Riccardi, R., Borghi-Cirri, M.B. et al. Localization of nitric oxide synthase immunoreactivity in mast cells of human nasal mucosa. Histochemistry 102, 89–92 (1994). https://doi.org/10.1007/BF00269011

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  • DOI: https://doi.org/10.1007/BF00269011

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