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Thrombomodulin distribution during murine development

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Abstract

Thrombomodulin is a transmembrane glycoprotein involved in the regulation of clot formation. Previous work has shown that in the adult mouse, thrombomodulin expression is primarily located on the luminal surface of endothelial cells; whereas during development, thrombomodulin has been localized to the placental parietal endoderm, the neuroepithelium, head mesenchyme, lung bud, and atrium of Day 10.5 post coitum embryos. We examined the expression of thrombomodulin in the adult mouse and throughout murine development from Day 7.5 to Day. 18.5 post coitum. The high expression of thrombomodulin in the lung bud, developing gonads, leptomeninges, and the parietal endoderm in comparison to the expression levels in the adult organs suggest that thrombomodulin may play an important role in development.

The submitted manuscript has been authored by a contractor of the U.S. Government under contract No. DE-AC05-840R21400. Accordingly, the U.S. Government retains nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for US Government purposes.

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Authors and Affiliations

  1. University of Tennessee, Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge, Tennessee

    Virginia A. Ford

  2. Biology Division, Oak Ridge National Laboratory, 37830-8025, Oak Ridge, Tennessee

    Stephen J. Kennel

  3. The University of Tennessee, Knoxville Veterinary School, Knoxville, Tennessee

    John E. Wilkinson

Authors
  1. Virginia A. Ford
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  2. John E. Wilkinson
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  3. Stephen J. Kennel
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Additional information

Research sponsored jointly by NIH Cancer Training Grant NIH-CA 09104, The University of Tennessee, and the Office of Health and Environmental research, U.S. Department of Energy, under contract DE-AC05-840R21400 with the Martin Marietta Energy Systems, Inc.

Correspondence to: S.J. Kennel

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Ford, V.A., Wilkinson, J.E. & Kennel, S.J. Thrombomodulin distribution during murine development. Roux's Arch Dev Biol 202, 364–370 (1993). https://doi.org/10.1007/BF00188735

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  • DOI: https://doi.org/10.1007/BF00188735

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