Summary
Lung tissue from 14 normal residents of high altitude regions, 10 patients with chronic bronchitis and emphysema, and 1 patient with Pickwickian syndrome was studied with regard to the occurrence of pulmonary vascular changes. In addition to the well-known pulmonary arterial alterations, lesions in small pulmonary veins were found in the great majority of the cases. These changes, consisting of medial hypertrophy and arterialization and of bundles of smooth muscle cells within the venous intima, have not been described before in man. These findings suggest that alveolar hypoxia acts not only on small pulmonary arteries and arterioles but also on veins of small caliber, probably by inducing venoconstriction.
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References
Bergofsky, E.H.: Mechanism underlying vasomotor regulation of regional pulmonary blood flow in normal and disease states. Amer. J. Med. 57, 378–394 (1974)
Estes, E.H., Sieker, H.O., McIntosh, H.D., Kelser, G.A.: Reversible cardiopulmonary syndrome with extreme obesity. Circulation 16, 179–187 (1957)
Fishman, A.P.: Hypoxia on the pulmonary circulation. How and where it acts. Circulat. Res. 38, 221–231 (1976)
Hasleton, P.S., Heath, D.. Brewer, D.B.: Hypertensive pulmonary vascular disease in states of chronic hypoxia. J. Path. Bact. 95, 431–440 (1968)
Hicken, P., Heath, D., Brewer, D.B., Whitaker, W.: The small pulmonary arteries in emphysema. J. Path. Bact. 90, 107–114 (1965)
Kuida, H., Tsagaris, T.J., Hecht, H.H.: Evidence for pulmonary venoconstriction in brisket disease. Circulat. Res. 12, 182–189 (1963)
Naeye, R.L.: Pulmonary vascular changes with chronic unilateral pulmonary hypoxia. Circulat. Res. 17, 160–167 (1965)
Wagenvoort, C.A.: Morphologic changes in intrapulmonary veins. Human Path. 1, 205–213 (1970)
Wagenvoort, C.A., Wagenvoort, N.: Hypoxic pulmonary vascular lesions in man at high altitude and in patients with chronic respiratory disease. Path. Microbiol. 39, 276–282 (1973)
Westcott, R.N., Fowler, N.O., Scott, R.C., Havenstein, V.D., McGrure, J.: Anoxia and human pulmonary vascular resistance. J. clin. Invest. 30, 957–970 (1951)
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Wagenvoort, C.A., Wagenvoort, N. Pulmonary venous changes in chronic hypoxia. Virchows Arch. A Path. Anat. and Histol. 372, 51–56 (1976). https://doi.org/10.1007/BF00429716
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DOI: https://doi.org/10.1007/BF00429716