Summary
An ultrastructural study of 11 myxofibrosarcomas is presented. The tumours were graded light-microscopically on a four-point scale according to cellularity, cell atypia and mitotic activity, as described in a previous paper: 3 were grade I, 2 grade II, 4 grade III and 2 grade IV.
Fibroblast-like and myofibroblast-like cells predominated in the grade I and II tumours, while histiocyte-like cells were relatively few; in grade III and IV tumours histiocyte-like cells predominated. The fibroblast-like cells were spindle-shaped with fairly smoothly outlined nuclei, and contained abundant parallel membranes and wide cisternae of endoplasmic reticulum. The histocyte-like cells were irregular in shape and showed indented nuclei with large nucleoli and coarse, peripherally arranged clumps of heterochromatin. The cytoplasm of these cells showed prominent pseudopodiae, microvillous projections, conspicuous systems of vesicles and vacuoles, inclusions of lipid and pigment, numerous lysosomal structures and large digestive vacuoles indicating auto- and exophagocytosis. The myofibroblast-like cells showed abundance of parallelly arranged cytoplasmic microfilaments with dense body-like structures and condensation at the plasmic membrane. Occasional cells appeared to be intermediate forms and primitive looking, undifferentiated cells were also encountered. A few multinucleated tumours cells were seen in the grade IV tumours. Thus, the present study shows the composite fibroblastic, myofibroblastic and histiocytic character of the tumour cells of myxofibrosarcoma; the grade III and IV tumours, with a tendency to contain solid areas, seem to be closely related to the pleomorphic type of malignant fibrous histiocytoma.
Similar content being viewed by others
References
Alguacil-Garcia, A., Unni, K.K., Goellner, J.R.: Malignant giant cell tumor of soft parts — an ultrastructural study of four cases. Cancer40, 244–253 (1977)
Angervall, L., Enerbäck, L., Knutsson, H.: Chondrosarcoma of soft tissue origin. Cancer32, 507–513 (1973)
Angervall, L., Kindblom, L.G., Merck, C.: Myxofibrosarcoma — a study of 30 cases. Acta path. microbiol. scand. Sect. A,85, 127–140 (1977)
Barr, R.J., Wuerker, R.B., Graham, J.H.: Ultrastructure of atypical fibroxanthoma. Cancer40, 736–743 (1977)
Churg, A.M., Kahn, L.B.: Myofibroblasts and related cells in malignant fibrous and fibrohistiocytic tumors. Human Pathol.8, 205–218 (1977)
Dahl, I.: Atypical fibroxanthoma of the skin — a clinicopathological study of 57 cases. Acta path. microbiol. scand. Sect. A,84, 183–197 (1976)
Dahl, I., Angervall, L.: Cutaneous and subcutaneous leiomyosarcomas — a clinicopathologic study of 47 patients. Path. Europ.9, 307–315 (1974)
Feldman, P.S., Horvath, E., Kovacs, K.: An ultrastructural study of seven cardiac myxomas. Cancer40, 2216–2232 (1977)
Fu, Y.-S., Kay, S.: A comparative ultrastructural study of mesenchymal chondrosarcoma and myxoid chondrosarcoma. Cancer33, 1531–1542 (1974)
Fu, Y.-S., Gabbiani, G., Kaye, G.I., Lattes, R.: Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): general considerations and electron microscopic and tissue culture studies. Cancer35, 176–198 (1975)
Jeanloz, R.W.: The nomenclature of mucopolysaccharides. Artritis Rheum.3, 233–237 (1960)
Kindblom, L.G., Angervall, L.: Histochemical characterization of mucosubstances in bone and soft tissue tumors. Cancer36, 985–994 (1975)
Kindblom, L.G., Säve-Söderbergh, J.: The ultrastructure of liposarcoma: a study of 10 cases. Acta path. microbiol. Scand. Sect. A. (In press)
Leak, L.V., Caulfield, J.B., Burke, J.F., McKhann, C.F.: Electron microscopic studies on a human fibromyxosarcoma. Cancer Res.27, 261–285 (1967)
Leppi, T.J., Stoward, P.J.: On the use of testicular hyaluronidase for identifying acid mucins in tissue sections. J. Histochem. Cytochem.13, 406–407 (1965)
Merkow, L.P., Frich, J.C., Slifkin, M., Kyreages, C.G., Pardo, M.: Ultrastructure of fibroxanthosarcoma (malignant fibroxanthoma). Cancer28, 372–383 (1971)
Ozzello, L., Hamels, J.: The histiocytic nature of dermatofibrosarcoma protuberans — tissue culture and electron microscopic study. Am. J. Clin. Path.65, 136–148 (1976)
Smith, M.T., Farinacci, C.J., Carpenter, H.A., Bannayan, G.A.: Extraskeletal myxoid chondrosarcoma — a clinicopathological study. Cancer37, 821–827 (1976)
Taxy, J.B., Battifora, H.: Malignant fibrous histiocytoma — an electron microscopic study. Cancer40, 254–267 (1977)
Weiss, S.W., Enzinger, F.M.: Myxoid variant of malignant fibrous histiocytoma. Cancer39, 1672–1685 (1977)
Weedon, D., Kerr, J.F.R.: Atypical fibroxanthoma of skin: an electron microscopic study. Pathology7, 173–177 (1975)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kindblom, L.G., Merck, C. & Angervall, L. The ultrastructure of myxofibrosarcoma. Virchows Arch. A Path. Anat. and Histol. 381, 121–139 (1979). https://doi.org/10.1007/BF01257879
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01257879