Summary
Experimental autoallergic sialadenitis was induced in SL/Ni mice by one or two injections of syngeneic submandibular gland homogenate emulsified with adjuvant. Light microscopically, there were marked lymphoid cell infiltration in the submandibular glands with high incidence and proliferation of duct epithelia. Furthermore complete alteration of whole glandular lobules in some cases was observed. Ultrastructurally, small and medium sized lymphocytes and plasma cells constituted a major portion of the infiltrating cells, and lymphocytes were frequently observed inside the basal lamina of ductal and acinar regions, especially observed in the small ductal region. In the aggregates of infiltrating cells, the cell remnants of salivary gland epithelia were scattered. Furthermore some of the epithelial cell remnants in aggregates of infiltrating cells could be recognized as epithelial masses which were composed of proliferated duct epithelial cells, though no typical structure of epimyoepithelial islands seen in Sjögren's syndrome was found. Anti-salivary duct antibody was detected in only one case.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Anderson LG, Tarpley TM, Talal N, Cummings NA, Wolf RO, Schall GL (1973) Cellular-versus-humoral autoimmune responses to salivary gland in Sjögren's syndrome. Clin Exp Immunol 13:335–342
Boquist L, Kumlien A, Östberg Y (1970) Ultrastructural findings in a case of benign lympho-epithelial lesion (Sögren's syndrome). Acta Otolaryngol (Stockh) 70:216–226
Boss JH, Rosenmann E, Sela J (1977) Experimental allergic sialoadenitis, X. Chronic destructive parotitis indiced in immunized rat by daily intraductal challenges with antign. J Oral Pathol 6:96–105
Carlsöö B, Östberg Y (1978) Ultrastructural observation on the parotitis autoimmunica in the NZB/NZW hybrid mice. Acta Otolaryngol 85:298–306
Chan WC (1964) Experimental sialo-adenitis in guinea-pigs. J Pathol Bacteriol 88:592–595
Chrisholm DM, Mason DK (1968) Labial salivary gland biopsy on Sjögren's disease. J Clin Pathol 21:656–600
Donath K, Seifert G (1972) Ultrastruktur und Pathogenese der myoepithelialen Sialadenitis. Virchows Arch [Pathol Anat] 356:315–329
Feltkamp TEW, Rossum AL (1968) Antibody to salivary duct cells, and other autoantibodies, in patients with Sjögren's syndrome and other idiopathic autoimmune diseases. Clin Exp Immunol 3:1–16
Greenspan JS, Gutman GA, Weissman IL, Talal N (1974) Thymus-antign and immunoglobulin-positive lymphocytes in tissue infiltrates of NZB/NZW mice. Clin Immunol Immunopathol 3:16–31
Kessler HS (1968) A laboratory model for Sjögren's syndrome. Am J Pathol 52:671–685
Keyes GG, Vickers RA, Kersey JH (1977) Immunopathology of Sjögren-like disease in NZB/ NZW mice. J Oral Pathol 6:228–295
Kyogoku M (1980) Pathogenesis of vasculitis in the SL/Ni mouse. In: Japan Medical Research Fundation (ed). Systemic lupus erythematosus. Univ Tokyo Press, Tokyo, pp 281–294
MacSween RNM, Goudie RB, Anderson JR, Armstrong E, Murray MA, Mason DK, Boyle JA, Buchanan WW, Williamson JW (1967) Occurrence of antibody to salivary duct epithelium in Sjögren's disease, rheumatoid arthritis, and other arthritides, A clinical and laboratory study. Ann Rheum Dis 26:402–411
McCabe BF (1961) The evidence for an autoimmune mechanism in Mukulicz's disease. Laryngoscope 71:396–403
Sharawy M, White SC (1978) Morphometric and fine structural study of experimental auto-allergic sialadenitis of rat submandibular glands. Virchows Arch [Pathol Anat] 28:255–273
Takeda Y (1980) Histopathological studies of the labial salivary glands in patients with Sjögren's syndrome, II. Electron microscopic study. Bull Tokyo Med Dent Univ 27:27–42
Takeda Y, Suzuki A, Komori A, Ishikawa G (1981) Histopathological study of the salivary glands in SL/Ni mice. Jpn J Oral Biol 23:427–438
Waterhouse JP (1963) Focal adenitis in salivary and lacrimal glands. Proc Roy Soc Med 56:25–32
Whaley K, MacSween RNM (1974) Experimental induction for immune sialadenitis in guinea-pigs using different adjuvents. Clin Exp Immunol 17:681–684
White SC (1973) Experimental autoallergic parotitis. J Oral Pathol 2:341–343
White SC, Casarett GW (1974) Induction of experimental autoallergic sialadenitis. J Immunol 112:178–185
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Takeda, Y., Ishikawa, G. Experimental autoallergic sialadenitis in mice. Vichows Archiv A Pathol Anat 400, 143–154 (1983). https://doi.org/10.1007/BF00585496
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00585496