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Immunohistochemical distribution of human epidermal growth factor in salivary gland tumours

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Summary

Immunohistochemical identification of human epidermal growth factor (hEGF) was carried out in a total of 152 cases of salivary gland tumours, consisting 107 pleomorphic adenomas and their variants, 13 adenolymphomas and 32 adenoid cystic carcinomas. A high percentage of pleomorphic adenomas revealed markedly positive hEGF staining of the luminal surface cells of tubuloductal structures and of modified or neoplastic myoepithelial cells. Clear cells of the tumour showed various reactivities from very slight to strong. Eosinophilic epithelial cells of adenolymphoma gave a positive reaction for hEGF in all the cases, whereas most adenoid cystic adenoma lacked hEGF staining; however some cases showed positive staining of the tumour cells. The immunohistochemical detection of hEGF in most salivary gland tumours suggests this factor to be a possible new marker of salivary glands tumours, and to have a biological role in tumour proliferation.

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Authors and Affiliations

  1. Department of Oral Surgery, Asahi University School of Dentistry, Hozumi, Motosu-gun, 501-02, Gifu, Japan

    M. Mori, R. Naito & Y. Okada

  2. Department of Dentistry, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, 602, Kyoto, Japan

    K. Tsukitani

  3. Central Resarch Laboratories, Wakunaga Pharmaceutical Co., Ltd., 1624 Shimokotachi, Koda-cho, Takata-gun, 729-64, Hiroshima, Japan

    T. Hayashi & K. Kato

Authors
  1. M. Mori
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  2. R. Naito
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  3. K. Tsukitani
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  4. Y. Okada
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  5. T. Hayashi
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  6. K. Kato
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Mori, M., Naito, R., Tsukitani, K. et al. Immunohistochemical distribution of human epidermal growth factor in salivary gland tumours. Vichows Archiv A Pathol Anat 411, 499–507 (1987). https://doi.org/10.1007/BF00713280

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  • DOI: https://doi.org/10.1007/BF00713280

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