Summary
A retrospective analysis of the prognostic value of pretreatment histology and expression of human chorionic gonadotrophin (B-hCG) was carried out in 100 invasive (T2/T3) transitional cell carcinomas of the bladder treated in a uniform manner. After transurethral resection of the tumour, all patients received a course of radical radiotherapy, with salvage cystectomy for those who failed to respond. Forty-nine of 100 patients responded to radiation; thus 51 did not. Forty-seven of 60 (78%) patients whose tumours contained areas of squamous differentiation and 22 of 29 (76%) of tumours staining positively for HCG failed to respond to radiotherapy. Twenty-two of 23 (96%) patients with tumours that had both these features did not respond to radiotherapy. The other histological features studied (grade of tumour, necrosis, inflammation, vascular invasion, and growth pattern) appeared unrelated to each other or to clinical outcome.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Blandy JP, England HR, Evans JW, Hope-Stone HF, Mair GMM, Mantell BS, Oliver RTD, Paris AMI, Risdon RA (1980) T3 bladder cancer - the case for salvage cystectomy. Br J Urol 52:506–510
Boileau MA, Johnson DE, Chan RC, Gonzales MO (1980) Bladder carcinoma. Results with preoperative radiation therapy and radical cystectomy. Br J Urol 16:569–576
Braunstein GD, Vaitukaitis JL, Carbone PP, Ross GT (1973) Ectopic production of human chorionic gonadotrophin by neoplasms. Ann Intern Med 78:39–45
Campo E, Palacin A, Benasco C, Quesada E, Cardesa A (1985) Human chorionic gonadotrophin in colorectal carcinoma, an immunohistochemical study. Cancer 59:1611–1616
Collino C, Stephenson C, Baithun SI, Cox E, Chard T, Oliver RTD (1986) Human chorionic gonadotrophin production by transitional cell carcinoma of the bladder. Abstract J Pathol 149:248
Crocker J, Smith PJ (1984) Immunohistochemical localisation of factor VIII related antigen in Hodgkins disease. J Clin Pathol 37:37–44
Hope-Stone HF (1986) Urothelial malignancies. In: Hopestone HF (ed) Radiotherapy in clinical practice. Chapter 3, London, Butterworth, pp 27–68
Jenkins BJ, Caulfield MJ, Fowler CG, Badenoch DF, Tiptaft RC, Oliver RTD, Blandy JPB (1988) Reappraisal of the role of radical radiotherapy and salvage cystectomy in the treatment of invasive T2/T3 bladder cancer. Br J Urol 62:343–347
Jewett HJ, King LR, Shelley WM (1964) A study of 365 cases of infiltrating bladder cancer; relation of certain pathological characteristics to prognosis after extirpation. J Urol 92:668–678
Pomerance A (1972) Pathology and prognosis following total cystectomy for carcinoma of the bladder. Br J Urol 44:451–458
Rodenburg CJ, Nieuwenhuyzen Kruseman AC, DeMaaker HA, Fieuren EJ, Van Oosterom AT (1985) Immunohistochemical localisation and chromatographic characterisation of human chorionic gonadotrophin in a bladder carcinoma. Arch Pathol Lab Med 109:1046–1049
Shah VM, Newman J, Crocker J, Chapple CR, Collard MJ, O'Brien JM, Considine JC (1986) Arch Pathol Lab Med 110:107–111
Slack NH, Prout GR (1980) The heterogeneity of invasive bladder carcinoma and different responses to treatment. J Urol 123:644–652
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Martin, J.E., Jenkins, B.J., Zuk, R.J. et al. Human chorionic gonadotrophin expression and histological findings as predictors of response to radiotherapy in carcinoma of the bladder. Vichows Archiv A Pathol Anat 414, 273–277 (1989). https://doi.org/10.1007/BF00822032
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00822032