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Influence of adrenalectomy on “Gomori-positive” substances in the hypothalamo-neurohypophysial system of rats heterozygous and homozygous for hypothalamic diabetes insipidus

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Summary

The influence of adrenalectomy on the amount of “Gomori-positive” neurosecretory material in the outer layer of the median eminence and in the supraoptico-hypophysial system was studied in normal Long-Evans rats and in Long-Evans rats heterozygous and homozygous for hypothalamic diabetes insipidus.

In all non-adrenalectomized rats very few “Gomori-positive” granules were found in the outer median eminence layer. After adrenalectomy the amount of the granules increased markedly in normal Long-Evans rats and only slightly in Long-Evans rats heterozygous for diabetes insipidus. However, no augmentation of the granules occurred in homozygous diabetes insipidus rats. The amount of “Gomori-positive” substances demonstrable in the supraoptic and paraventricular nuclei, in the inner layer of the median eminence, and in the neural lobe of the hypophysis was less in rats heterozygous for diabetes insipidus than in normal Long-Evans rats and the smallest in homozygous diabetes insipidus rats. No differences in the amounts of the substances were observed between adrenalectomized and non-adrenalectomized animals.

The findings suggest that the “Gomori-positive” granules occurring in the outer layer of the median eminence of adrenalectomized rats are of similar origin as those of the supraoptico-hypophysial system and represent a vasopressin-neurophysin-complex. The results support the concept that vasopressin is involved in the regulation of ACTH release.

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Authors and Affiliations

  1. Anatomisches Institut der Universität Bonn, Nußallee 10, D-5300, Bonn, Federal Republic of Germany

    P. E. Schwabedal

  2. Fachrichtung Anatomie im Fachbereich Theoretische Medizin der Universität des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany

    R. Bock

  3. Postgraduate School of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand

    W. B. Watkins

  4. Pharmakologisches Institut der Universität Heidelberg, Im Neuenheimerfeld 366, D-6900, Heidelberg, Federal Republic of Germany

    J. Möhring

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  1. P. E. Schwabedal
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  2. R. Bock
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  3. W. B. Watkins
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  4. J. Möhring
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This work was supported by grants from the Deutsche Forschungs-gemeinschaft (Bo 392/2) and from the Medical Research Council of New Zealand.

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Schwabedal, P.E., Bock, R., Watkins, W.B. et al. Influence of adrenalectomy on “Gomori-positive” substances in the hypothalamo-neurohypophysial system of rats heterozygous and homozygous for hypothalamic diabetes insipidus. Anat Embryol 151, 81–89 (1977). https://doi.org/10.1007/BF00315300

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