Summary
The trachea of the guinea-pig measures about 47.5 mm in situ, and it shrinks to 38 mm when excised. It can be stretched to the in situ length with a load of 2–4 grams. The transverse area of its lumen measures about 4.5 mm2 in the cervical portion, whereas in the lowermost thoracic portion it measures 2.8 mm2, a difference of 37%. The lumen has an oval shape with the transverse diameter always exceeding the sagittal diameter. The separation between the ends of a cartilage in the dorsal region of the trachea is greater in the cervical than in the thoracic region. Elastic fibres are abundant in the tunica propria and run longitudinally; the collagen is in some areas arranged with a criss-cross pattern. The muscle is inserted on the concave aspect of each cartilage at some distance from the ends of the cartilage and it is therefore much longer than the gap between cartilage ends. Upon contraction in vitro (induced by carbachol) the muscle shortens by about 50%; there is a marked decrease of the transverse diameter of the trachea, and a certain decrease also of the sagittal diameter due to a straightening of the muscle and a change in shape and a movement of the mucosa. The cartilage ends are brought together and in the thoracic region they are bent and overlap extensively. The lumen of the trachea becomes circular and its area is reduced to 2.2 mm2 in the cervical portion and 1.7 mm2 in the thoracic portion.
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References
Blackman JG, McCaig DJ (1982) Studies on an isolated innervated preparation of guinea-pig trachea. Br J Pharmacol 80:703–710
Baluk P, Fujiwara T, Matsuda S (1985) The fine structure of the ganglia of the guinea-pig trachea. Cell Tissue Res 239:51–60
Brown JG, Webster PM, Zamel N, Hoffstein V (1986) Changes in tracheal cross-sectional area during Mueller and Valsalva maneuvers in humans. J Appl Physiol 60:1865–1870
Cameron AR, Bullock CG, Kirkpatrick CT (1982) The ultrastructure of bovine tracheal smooth muscle. J Ultrastruct Res 81:290–305
Cherown SE, Venugopalan CS, Gold WM, Drazen JM (1980) In vivo demonstration of noradrenergic inhibitory innervation of the guinea pig trachea. J Clin Invest 65:314–320
Dixon JS, Small RC (1983) Evidence of poor conduction of muscle excitation in the longitudinal axis of guinea-pig isolated trachea. Br J Pharmacol 79:75–83
Gabella G (1987) The cross-ply arrangement of collagen fibres in the submucosa of the mammalian small intestine. Cell Tissue Res 248:491–497
Goerttler K (1932) Der konstuktive Bau der menschlichen Darmwand. Morphol Jahrb 69:329–379
Horsfield K (1987) Morphometry of airways. In: Macklem PT, Mead J, Geiger SR (eds) Handbook of Physiology. Sect 3: The Respiratory System. Vol III: Mechanics of Breathing, part 1. Physiol Soc, Bethesda (Wash), pp 75–88
Hoyes AD, Barber P (1980) Innervation of the trachealis muscle in the guinea-pig: a quantitative ultrastructural study. J Anat (Lond) 130:789–800
Jones TR, Kannan MS, Daniel EE (1980) Ultrastructural study of guinea pig tracheal smooth muscle and its innervation. Cancer J Physiol Pharmacol 58:974–983
Kirkpatrick CT (1980) Tracheobronchial smooth muscle. In: Bulbring E, Brading AF, Jones AW, Tomita T (eds) Smooth muscle: An assessment of current knowledge. Edward Arnold, London, pp 385–395
Leeson CR (1963) Histology, histochemistry and electron microscopy of transitional epithelium of the rat urinary bladder in response to induced physiological changes. Acta Anat 48:297–315
Lundberg JM, Brodin E, Hua X, Saria A (1984) Vascular permeability changes and smooth muscle contraction in relation to capsaicin-sensitive substance P afferents in the guinea-pig. Acta Physiol Scand 120:217–227
Macklin CC (1929) The musculature of the bronchi and lungs. Physiol Rev 9:1–60
Nadel JA, Barnes PJ, Holtzman MJ (1987) Autonomic factors in hyperreactivity of airway smooth muscle. InL Macklem PT, Mead J, Geiger SR (eds) Handbook of Physiology. Sect 3: The Respiratory System. Vol III: Mechanics of Breathing, part 1. Am Physiol Soc, Bethesda (Wash), pp 693–702
Negus V (1965) The Biology of Respiration. Livingston, London
Small RC (1982) Electrical slow waves and tone of guinea-pig isolated tracheal muscle: effects of drugs and temperature changes. Br J Pharmacol 77:45–54
Smith RV, Satchell DG (1985) Extrinsic pathways of the adrenergic innervation of the guinea-pig trachealis muscle. J Auton Nerv Syst 14:61–73
Souhrada JF, Dickey DW (1976a) Mechanical activities of trachea as measured in vitro and in vivo. Respir Physiol 26:27–40
Souhrada JF, Dickey DW (1976b) Effect of antigen challenge on sensitized guinea pig trachea. Respir Physiol 27:241–251
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Amiri, M.H., Gabella, G. Structure of the guinea-pig trachea at rest and in contraction. Anat Embryol 178, 389–397 (1988). https://doi.org/10.1007/BF00306045
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DOI: https://doi.org/10.1007/BF00306045