Skip to main content
SpringerLink
Log in

Fetal mouse weights and albumin/α1-fetoprotein ratios after maternal infection with Coxsackievirus B3

  • Published:
Medical Microbiology and Immunology Aims and scope Submit manuscript

Abstract

The injection of pregnant mice with Coxsackievirus B3 results in a reduction of fetal weights and retarded development of the albumin/α1-fetoprotein ratio which can be measured by using the Laurell two-dimensional immunoelectrophoretic technique. The litter weights tended to be lower in litters with a low albumin/α1-fetoprotein ratio and from an analysis of covariance the results indicate that the effect of the virus on fetal weights can not all be accounted for by the effect on maturation.

It is suggested that the mouse model system studied may be of value for demonstrating retarded fetal and neonatal maturation as a result of inapparent virus infection, and possibly from other causes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Coid, C. R.: In Intrauterine Infections (Ciba Found. Symp.), pp. 117–130. Amsterdam: Associated Scientific Publishers 1973

    Google Scholar 

  • Coid, C. R., Ramsden, D. B.: Retardation of foetal growth and plasma protein development in foetuses from mice injected with Coxsackie B3 virus. Nature (Lond.)241, 460–461 (1973)

    Article  Google Scholar 

  • Davies, D. R., Spurr, E. D., Versey, J. B.: Modifications to the technique of two-dimensional immunoelectrophoresis. Clin. Sci.40, 411–417 (1971)

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. D. B. Ramsden

    Present address: Dept. of Medicine, University of Birmingham, UK

Authors and Affiliations

  1. M.B.C. Clinical Besearch Centre, HA1 3UJ, Harrow, Middlesex

    C. R. Coid, D. B. Ramsden & M. J. R. Healy

Authors
  1. C. R. Coid
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. B. Ramsden
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. J. R. Healy
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Coid, C.R., Ramsden, D.B. & Healy, M.J.R. Fetal mouse weights and albumin/α1-fetoprotein ratios after maternal infection with Coxsackievirus B3. Med Microbiol Immunol 159, 285–288 (1974). https://doi.org/10.1007/BF02123738

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02123738

Keywords

Search

Navigation