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Immunity to influenza in ferrets

XIII. Protection against influenza infection by serum antibody to homologous haemagglutinin or neuraminidase antigens

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Abstract

Ferrets were infected with recombinant influenza A viruses which possessed either the haemagglutinin or neuraminidase antigens of A/Hong Kong/68 influenza virus. After five weeks the immunity of the animals was challenged by infection with A/HK/68 virus. Immunity to challenge infection was greatest in those ferrets with serum HI antibody to A/HK/68; the presence of NI antibody conferred a measurably lower degree of immunity. A small degree of heterotypic immunity was observed following challenge infection of ferrets previously infected with influenza virus A/PR/8/34, although the surface antigens of this virus are completely different from those of A/HK/68. Experiments in which ferrets were infected with A/HK/68 virus and subsequently challenged with the recombinant viruses confirmed the results of the first experiment.

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Authors and Affiliations

  1. Department of Medical Microbiology, University of Sheffield Medical School, Sheffield, England

    C. McLaren (Independent Research Worker, Department of Medicine), C. W. Potter & R. Jennings

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  1. C. McLaren
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  2. C. W. Potter
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  3. R. Jennings
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Independent Research Worker, Department of Medicine.

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McLaren, C., Potter, C.W. & Jennings, R. Immunity to influenza in ferrets. Med Microbiol Immunol 160, 33–45 (1974). https://doi.org/10.1007/BF02124341

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  • DOI: https://doi.org/10.1007/BF02124341

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