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Osteogenic sarcoma complicating osteogenesis imperfecta tarda

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Abstract

We describe the case history of a 13 years old boy who developed osteogenic sarcoma of the left thigh, six years after diagnosis of osteogenesis imperfecta tarda with a positive family history. Only four other patients with this disease combination are reported in the literature.

Preoperative treatment with high-dose Methotrexate caused marked tumor regression, as shown at examination of amputation material. The inter-relationships between the two disorders are discussed and the literature is briefly reviewed.

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Authors and Affiliations

  1. Department of Pediatrics, University Hospitals, Schwanenweg 20, D-2300, Kiel 1, Federal Republic of Germany

    U. Lasson & H. -R. Wiedemann

  2. Department of Paidopathology, University Hospitals, Schwanenweg 20, D-2300, Kiel 1, Federal Republic of Germany

    D. Harms

Authors
  1. U. Lasson
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  2. D. Harms
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  3. H. -R. Wiedemann
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Lasson, U., Harms, D. & Wiedemann, H.R. Osteogenic sarcoma complicating osteogenesis imperfecta tarda. Eur J Pediatr 129, 215–218 (1978). https://doi.org/10.1007/BF00442166

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  • DOI: https://doi.org/10.1007/BF00442166

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