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The effect of oral calcium carbonate administration on serum lipoproteins of children with familial hypercholesterolaemia (type II-A)

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Abstract

The effect of oral calcium carbonate on serum lipoprotein concentrations was tested in 50 children with familial hypercholesterolemia (type II-A) consuming a low cholesterol high polyunsaturated fat diet, using a cross-over design versus a placebo. Cholesterol was measured in serum and in the individual lipoprotein density classes. Serum apolipoprotein B (the protein moiety of low density lipoprotein) and apolipoprotein A-I (the main protein of high density lipoprotein) were measured by specific immunoassays. Calcium carbonate treatment induced only a slight increase in serum apolipoprotein A-I (+4%) and a slight decrease in low density lipoprotein cholesterol (-4%), both changes being significant at the P=0.05 level.

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References

  1. Albrink MJ, Meigs JW, Man EB (1961) Serum lipids, hypertension and coronary artery disease. Am J Med 13:4–23

    Google Scholar 

  2. Bhattacharyya AK, Thera C, Anderson JT, Grande F, Keys A (1969) Dietary calcium and fat: Effects on serum lipids and fecal excretion of cholesterol and its degradation products in man. Am J Clin Nutr 22:1161–1174

    Google Scholar 

  3. Bierenbaum ML, Fleischman AI, Raichelson RI (1972) Long term human studies on the lipid effects of oral calcium. Lipids 7:202–206

    Google Scholar 

  4. Boehringer, Produktprofile Monotest cholesterol CHODPAP method, Mannheim, GFR

  5. Carlson LA, Böttiger LE (1972) Ischemic heart disease in relation to fasting values of plasma triglycerides and cholesterol. Lancet I:865–868

    Google Scholar 

  6. Carlson LA, Olsson AG, Orö L, Rössner S (1971) Effects of oral calcium upon serum cholesterol and triglycerides in patients with hyperlipidemia. Atherosclerosis 14:391–400

    Google Scholar 

  7. Drenick EJ (1961) The influence of ingestion of calcium and other soap-forming substances on fecal fat. Gastroenterology 41:242–244

    Google Scholar 

  8. Fernandes J, Dijkhuis-Stoffelsma R, Grose W (1977) Hypercholesterolemic children (type II-A) treated with high-linoleic acid diet and cholestyramine: the effect on serum lipids and platelet aggregation. Acta Paediatr Scand 66:621–624

    Google Scholar 

  9. Fredrickson DS, Goldstein JL, Brown MS (1978) The familial hyperlipoproteinemias. In: Stanbury JB, Wijngaarden JB Fredrickson DS (eds) The Metabolic Basis of Inherited Disease. McGraw-Hill, New York, pp 605–655

    Google Scholar 

  10. Glueck CJ, Fallet R, Tsang R (1973) Pediatric familial type-II hypercholesterolemia—Therapy with diet and cholestyramine resin. Pediatrics 52:669–679

    Google Scholar 

  11. Gofman JW, Young W, Tandy R (1966) Ischemic heart disease, atherosclerosis and longlivity. Circulation 34:679–697

    Google Scholar 

  12. Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawler TR (1977) High density lipoprotein as a protective factor against coronary heart disease. Am J Med 62:707–714

    Google Scholar 

  13. Havel RJ, Eder HA, Bragdon JH (1955) The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 32:1345–1353

    Google Scholar 

  14. Horan JM, Di Luzio NR, Etteldorf JM (1964) Use of an anion exchange resin in treatment of two siblings with familial hypercholesterolemia. J Pediatr 64:201–209

    Google Scholar 

  15. Kannel WB, Castelli WP, Gordon T, et al. (1971) Serum cholesterol lipoproteins, and risk of coronary heart diseases. The Framingham study. Ann Intern Med 24:1–12

    Google Scholar 

  16. Koskinen P, Inkovaara J, Ala-Kaila K, Salo M, Nikkari T (1977) Effect of calcium p-chlorphenoxy isobutyrate and calcium carbonate on plasma lipids and lipopoteins of patients with hyperlipoproteinemia. Ann Clin Res 9:335–341

    Google Scholar 

  17. Laurell CB (1972) Electroimmunoassay. Scand J Clin Lab Invest 29 [Suppl] 124:21–37

    Google Scholar 

  18. Lees RS, Wilson DE (1971) The treatment of hyperlipidemia N Engl J Med 284:186–195

    Google Scholar 

  19. Maibach E (1967) Die Beeinflussung des Gesamtcholesterins, der β-Lipoproteide und Gesamtlipide des Serums durch orale und parenterale Calciumzufuhr. Schweiz Med Wochenschr 97:418–421

    Google Scholar 

  20. Maibach E (1968) deÜber die Beeinflussung des Gesamtcholesterins und der Gesamtlipide im Serum des Menschen durch orale Kalziumzufuhr. Wien Med Wochenschr 118:1059–1062

    Google Scholar 

  21. Miettinen M, Turpeinen O, Darvonen MJ, Elosno R, Paavilamien E (1972) Effect of cholesterol-lowering diet on mortality from coronary heart-disease and other causes. Lancet II: 835–838

    Google Scholar 

  22. Miller GJ, Miller NE (1975) Plasma high density lipoprotein concentration and development of ischaemic heart disease. Lancet I:16–19

    Google Scholar 

  23. Redgrave TG, Roberts DCK, West CE (1975) Separation of plasma lipoproteins by density-gradient ultracentrifugation. Anal Biochem 65:42–49

    Google Scholar 

  24. Slack J (1969) Risks of ischaemic heart disease in familial hyperlipoproteinemic states. Lancet II:1380–1382

    Google Scholar 

  25. Wells WW, Cooper SB (1958) Coprostenol formation II. The opposing action of dietary lactose and calcium on cholesterol absorption. Arch Biochem Biophys 75:273–285

    Google Scholar 

  26. West RJ, Lloyd JK (1973) Use of cholestyramine in treatment of children with familial hypercholesterolemia. Arch Dis Childh 48:370–374

    Google Scholar 

  27. Yacowitz H, Fleischman AI, Bierenbaum ML (1965) Effects of oral calcium upon serum lipids in man. Br Med J I: 1352–1354

    Google Scholar 

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Author notes

  1. J. Fernandes

    Present address: Department of Paediatrics, State University Groningen, Groningen, The Netherlands

Authors and Affiliations

  1. Department of Biochemistry I, Medical Faculty, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands

    P. H. E. Groot

  2. Department of Clinical Chemistry, Sophia Children's Hospital and Neonatal Unit, Erasmus University Rotterdam, The Netherlands

    W. F. A. Grose & J. J. Ambagtsheer

  3. Department of Paediatrics, Sophia Children's Hospital and Neonatal Unit, Erasmus University Rotterdam, The Netherlands

    W. F. A. Grose, R. Dijkhuis-Stoffelsma & J. Fernandes

Authors
  1. P. H. E. Groot
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  2. W. F. A. Grose
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  3. R. Dijkhuis-Stoffelsma
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  4. J. Fernandes
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  5. J. J. Ambagtsheer
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Groot, P.H.E., Grose, W.F.A., Dijkhuis-Stoffelsma, R. et al. The effect of oral calcium carbonate administration on serum lipoproteins of children with familial hypercholesterolaemia (type II-A). Eur J Pediatr 135, 81–84 (1980). https://doi.org/10.1007/BF00445899

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  • DOI: https://doi.org/10.1007/BF00445899

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