Abstract
Measurements of serum thyroxine (T4), thyroxine binding globulin (TBG), and triiodothyronine (T3), using RIA, were conducted in healthy Israeli boys. 149 children from the age 8 years were divided into five groups according to Tanner's puberty stages. The correlation with Tanner's staging showed a significant decrease in T4 and TBG concentrations during puberty. However, T3 decreased only toward the last stage of puberty (between P4 to P5). Our data indicate that during puberty in male subjects the decrease in TBG plays a significant role in the decrease of thyroid hormone concentrations.
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References
Avruskin TW, Tang SC, Shenkman L, Mitsuma T, Hollander CS (1973) Serum T3 concentrations in infancy, childhood and adolescence and pediatric thyroid disorders. J Clin Endocrinol 37:235–237
Dowling JT, Freinkel N, Ingbar SH (1958) Effect of diethylstilbestrol on the binding of thyroxine in serum. J Clin Endocrinol 16:1491–1506
Fisher DA, Sack J, Oddie TH, Pekary AE, Hershman JM, Lam RW, Parslow ME (1977) Serum T4, TBG, T3-uptake, reverse T3 and TSH concentrations in children 1–15 years of age. J Clin Endocrinol 45:191–198
Hays GC, Mullard JE (1974) Normal free thyroxine index values in infancy and childhood. J Clin Endocrinol Metab 39:958–960
Koivisto M, Simila S, Haapalakati G, Reinila M (1974) Thyroid function assay using the effective thyroxine ratio (ETR) in infancy. Scand J Clin Lab Invest 33:105–107
Marshall WA, Tanner JM (1970) Variations in pattern of pubertal changes in boys. Arch dis child 45:13–23
Oddie TH, Fisher DA (1967) Protein bound iodine level in euthyroid children and adolescents. J Clin Endocrinol 27:89–92
Parra A, Villalpando S, Junco E, Urquieta B, Altorre S, Garcia Bulnes G (1980) Thyroid gland function during childhood and adolescence, changes in serum TSH, T4, T3, thyroxine binding globulin, reverse T3 and free T4 and T3 concentrations. Acta Endocrinologica 93:306–314
Rubenstein HA, Butler VP, Werner SC (1973) Progressive decrease in serum T3 concentrations with human aging: Radioimmunoassay following extraction of serum. J Clin Endocrinol 37:247–253
Ryness JJ (1972) The measurement of serum thyroxine in children. J Clin Pathol 25:726–729
Stubbe P, Gatz J, Heidemann P, vz Mühlen A, Hesch R (1978) Thyroxine binding globulin, triiodothyronine, thyroxine and thyrotropin in newborn infants and children. Horm Metab Res 10:58–61
Takeya T, Sato T, Nakajjima H (1974) Serum triiodothyronine levels in normal children. J Clin Endocrinol (Tokyo) 22:987–990
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Sack, J., Bar-On, Z., Shemesh, J. et al. Serum T4, T3 and TBG concentrations during puberty in males. Eur J Pediatr 138, 136–137 (1982). https://doi.org/10.1007/BF00441139
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DOI: https://doi.org/10.1007/BF00441139