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d-lactic acidosis in two patients with short bowel syndrome: Bacteriological analyses of the fecal flora

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Abstract

Two cases of d-lactic acidosis associated with short bowel syndrome are described. The administration of kanamycin to the patients showed a decrease in d-lactate in blood and urine in parallel with disappearance of metabolic acidosis. Bacteriological analyses of the fecal flora showed an increase in Lactobacillus buchneri in the first patient and Lactobacillus fermenti IVa in the second; both bacteria were sensitive to kanamycin. Quantification of in vitro production of d-lactate by each species of bacteria isolated from the feces revealed that Lactobacillus produced more d-lactate than other species of bacteria. These observations indicate that Lactobacillus may play an important role in the induction of d-lactic acidosis in patients with short bowel syndrome.

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References

  • Buchanan RE, Gibbons NE (1974) Bergy's manual of determinative bacteriology, 8th ed. The Williams and Wilkins Co., Baltimore

    Google Scholar 

  • Camien MN, Fowler AV, Dunn MS (1963) Free and bound intracellular lactic acid in lactobacillus casei and other organisms. J Biol Chem 238:1167–1174

    Google Scholar 

  • Cowan ST, Steel KJ (1965) Manual for the identification of medical bacteria. Cambridge at the University Press

  • Dunlop RH, Hammond PB (1965) d-lactic acidosis of ruminants. Ann NY Acad Sci 119:1109–1132

    Google Scholar 

  • Duran M, Van Biervliet JPGM, Kamering JP, Wadman SK (1977) d-lactic aciduria, an inborn error of metabolism? Clin Chim Acta 74:297–300

    Google Scholar 

  • Krogh N (1963) Clinical and microbiological studies on spontaneous cases of acute indigestion in ruminants. Acta Vet Scand 4:27–40

    Google Scholar 

  • Mitsuoka T (1969) Vergleichende Untersuchungen über die Laktobazillen aus den Faeces von Menschen, Schweinen und Hühnern. Zbl f Bakt, I Orig 210:32–51

    Google Scholar 

  • Mitsuoka T, Hayakawa K, Kimura N (1975) Die Fäkalflora bei Menschen. III. Mitteilung: Die Zusammensetzung der Laktobacillenflora der verschiedenen Altersgruppen. Zbl Bakt Hyg, I. Abt Orig A 232:499–511

    Google Scholar 

  • Oh MS, Phelps KR, Traube M, Berbosa-Saldivar JL, Boxhill C, Carroll HJ (1979) d-lactic acidosis in a man with the short-bowel syndrome. N Engl J Med 301:249–252

    Google Scholar 

  • Schoorel EP, Giersberts MAH, Blom W, Van Geldern HH (1980) d-lactic acidosis in a boy with short bowel syndrome. Arch Dis Childh 55:810–812

    Google Scholar 

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Satoh, T., Narisawa, K., Konno, T. et al. d-lactic acidosis in two patients with short bowel syndrome: Bacteriological analyses of the fecal flora. Eur J Pediatr 138, 324–326 (1982). https://doi.org/10.1007/BF00442509

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  • DOI: https://doi.org/10.1007/BF00442509

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