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Arachidonic acid and male genital differentiation

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Abstract

Arachidonic acid (AA) prevents neural tube defects, cleft palate, and micrognathia in the rat models of diabetic embryopathy and neural tube defects in the mouse embryo culture model. In this study, the involvement of AA in the male genital differentiation was described. These observations raise the complementary possibility that the AA-prostaglandin biochemical pathway may be a major mechanism mediating many embryonic events that involve cellular movement and fusion.

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Abbreviations

AA:

arachidonic acid

DPH:

diphenylhydantoin

PLIP:

phospholipase A-inhibiting proteins

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Authors and Affiliations

  1. Center for Craniofacial Anomalies, University of Illinois, College of Medicine at Chicago, 840 South Wood Street, PO Box 6998, 60612, Chicago, IL, USA

    A. S. Goldman

  2. Department of Pediatrics, University of Illinois, College of Medicine at Chicago, 840 South Wood Street, PO Box 6998, 60612, Chicago, IL, USA

    A. S. Goldman

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  1. A. S. Goldman
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Goldman, A.S. Arachidonic acid and male genital differentiation. Eur J Pediatr 146 (Suppl 2), S63–S66 (1987). https://doi.org/10.1007/BF00452878

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  • DOI: https://doi.org/10.1007/BF00452878

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