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Plasma and right auricle concentrations of atrial natriuretic polypeptide in children with cardiac diseases

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Abstract

To investigate the atrial natriuretic polypeptide (ANP) levels in congenital heart diseases, we measured plasma immunoreactive ANP (ir-ANP) in 29 patients with left-to-righ shunt, and right auricle ir-ANP in 25 patients who underwent operation. The levels of ir-ANP in the pulmonary artery correlated with that in the femoral vein (r=0.95, P<0.001), mean pulmonary arterial pressure (r=0.74, P<0.001) and right atrial pressure (r=0.53, P<0.01). The right auricle ir-ANP level was high in patients with heart failure combined with pressure or volume overload of the right atrium, as observed in tricuspid atresia, complete endocardial cushion defect, and total anomalous pulmonary venous drainage. These results suggest that the production of ANP in the atrium increases as a compensatory or secondary response to persistent release of ANP into the circulation in cardiac diseases.

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Abbreviations

ANP:

atrial natriuretic polypeptide

ir-ANP:

immunoreactive ANP

α-hANP:

alpha human ANP

VSD:

ventricular septal defect

ASD:

atrial septal defect

PDA:

patent ductus arteriosus

TOF:

tetralogy of Fallot

DORV:

double outlet right ventricle

TAPVD:

total anomalous pulmonary venous drainage

cECD:

complete endocardial cushion defect

TA:

tricuspid atresia

MRAP:

mean right atrial pressure

MPAP:

mean pulmonary arterial pressure

Qp/Qs:

pulmonary-to-systemic blood flow ratio

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Akimoto, K., Miyata, A., Kangawa, K. et al. Plasma and right auricle concentrations of atrial natriuretic polypeptide in children with cardiac diseases. Eur J Pediatr 147, 485–489 (1988). https://doi.org/10.1007/BF00441972

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  • DOI: https://doi.org/10.1007/BF00441972

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