Abstract
To investigate the atrial natriuretic polypeptide (ANP) levels in congenital heart diseases, we measured plasma immunoreactive ANP (ir-ANP) in 29 patients with left-to-righ shunt, and right auricle ir-ANP in 25 patients who underwent operation. The levels of ir-ANP in the pulmonary artery correlated with that in the femoral vein (r=0.95, P<0.001), mean pulmonary arterial pressure (r=0.74, P<0.001) and right atrial pressure (r=0.53, P<0.01). The right auricle ir-ANP level was high in patients with heart failure combined with pressure or volume overload of the right atrium, as observed in tricuspid atresia, complete endocardial cushion defect, and total anomalous pulmonary venous drainage. These results suggest that the production of ANP in the atrium increases as a compensatory or secondary response to persistent release of ANP into the circulation in cardiac diseases.
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Abbreviations
- ANP:
-
atrial natriuretic polypeptide
- ir-ANP:
-
immunoreactive ANP
- α-hANP:
-
alpha human ANP
- VSD:
-
ventricular septal defect
- ASD:
-
atrial septal defect
- PDA:
-
patent ductus arteriosus
- TOF:
-
tetralogy of Fallot
- DORV:
-
double outlet right ventricle
- TAPVD:
-
total anomalous pulmonary venous drainage
- cECD:
-
complete endocardial cushion defect
- TA:
-
tricuspid atresia
- MRAP:
-
mean right atrial pressure
- MPAP:
-
mean pulmonary arterial pressure
- Qp/Qs:
-
pulmonary-to-systemic blood flow ratio
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Akimoto, K., Miyata, A., Kangawa, K. et al. Plasma and right auricle concentrations of atrial natriuretic polypeptide in children with cardiac diseases. Eur J Pediatr 147, 485–489 (1988). https://doi.org/10.1007/BF00441972
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DOI: https://doi.org/10.1007/BF00441972